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α-Glucosidase-IN-23

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Catalog No. T67728Cas No. 161187-57-1

α-Glucosidase-IN-23 is an orally active inhibitor of α-glucosidase that can decrease blood glucose levels by inhibiting α-glucosidase (IC50 = 4.48 μM).

α-Glucosidase-IN-23

α-Glucosidase-IN-23

😃Good
Purity: 98.93%
Catalog No. T67728Cas No. 161187-57-1
α-Glucosidase-IN-23 is an orally active inhibitor of α-glucosidase that can decrease blood glucose levels by inhibiting α-glucosidase (IC50 = 4.48 μM).
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$118In StockIn Stock
5 mg$287In StockIn Stock
10 mg$392In StockIn Stock
25 mg$593In StockIn Stock
50 mg$798In StockIn Stock
100 mg$1,050-In Stock
200 mg$1,390-In Stock
1 mL x 10 mM (in DMSO)$343In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
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Batch Information

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Purity:98.93%
Appearance:Solid
Color:Yellow
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COA HNMR LCMS

Product Introduction

Bioactivity
Description
α-Glucosidase-IN-23 is an orally active inhibitor of α-glucosidase that can decrease blood glucose levels by inhibiting α-glucosidase (IC50 = 4.48 μM).
In vitro
α-Glucosidase-IN-23 (1 μM) exhibits significant anti-diabetes activity. α-Glucosidase-IN-23 decreases ROS levles in βcells and muscle cells. α-Glucosidase-IN-23 decreases blood glucose by α-glucosidase inhibition (IC50= 4.48 μM)[1].
In vivo
α- Glucosidase-IN-23 (oral; 0.2 mmol/kg/day) only inhibits α- Glucosidase in mice[1].
Chemical Properties
Molecular Weight373.4
FormulaC20H23NO6
Cas No.161187-57-1
SmilesC(OCC)(=O)C=1C(C(C(OCC)=O)=C(C)NC1C)C2=C3C(=CC=C2)OCO3
Relative Density.1.225 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 25 mg/mL (66.95 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.6781 mL13.3905 mL26.7809 mL133.9047 mL
5 mM0.5356 mL2.6781 mL5.3562 mL26.7809 mL
10 mM0.2678 mL1.3390 mL2.6781 mL13.3905 mL
20 mM0.1339 mL0.6695 mL1.3390 mL6.6952 mL
50 mM0.0536 mL0.2678 mL0.5356 mL2.6781 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

α-Glucosidase-IN-23αGlucosidaseIN23α-glucosidasealpha-Glucosidase-IN-23a-Glucosidase-IN-23
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