cha

β-NETA (α-NETA) is a stable, noncompetitive, slowly reversible choline acetyltransferase (ChAT) inhibitor with an IC50 of 9 μM and is a potent chemokine-like receptor-1 (CMKLR1) antagonist. β-NETA has anti-cancer activity[1][2]. β-NETA weakly inhibits cholinesterase (IC50=84 µM) and acetylcholinesterase (IC50=300 µM).

N6-Cyclohexyladenosine (CHA) is a selective agonist of A1 receptor with EC50 of 8.2 Nm. N6-Cyclohexyladenosine exerts anticonvulsant effects and protects against neuronal death. CHA was also found to inhibit the pressor effects of lumbar sympathetic nerve stimulation in rats.

Fmoc-Cha-OH (Fmoc-L-cyclohexylalanine) is an alanine derivative containing an Fmoc protecting group, which can be used for peptide synthesis and drug design.

Fmoc-D-Cha-OH (FDCO) is an apoptotic DNase γ inhibitor that inhibits the release of HMGB1.

6-Chloro-3-indolyl-β-D-Glucuronide (cyclohexylammonium salt) is a chromogenic substrate for β-glucuronidase and can be utilized in the histochemical analysis of β-glucuronidase activity.

Dnp-P-Cha-G-Cys(Me)-HA-K(Nma)-NH2 is a fluorogenic substrate for matrix metalloproteinase-1 (MMP-1) and MMP-9. Upon cleavage by MMP-1 or MMP-9, N-methylanthranilic acid (Nma) is unquenched and its fluorescence can be used to quantify MMP activity. Nma displays excitation/emission spectra of 340/440 nm, respectively.

Boc-Cha-OMe is a useful organic compound for research related to life sciences. The catalog number is T65020 and the CAS number is 98105-41-0.

Ac-D-DGla-LI-Cha-C is a potent peptide inhibitor of the HCV protease, useful in research targeting various diseases, including cancer, autoimmune, fibrotic, inflammatory, neurodegenerative, infectious, lung, heart and vascular, and metabolic diseases [1].

Ala-parafluoroPhe-Arg-Cha-Cit-Tyr-NH2 is a biologically active peptide functioning as a selective agonist for Protease Activated Receptor 1 (PAR-1) [a subtype of G-protein coupled receptors involved in mediating thrombin's cellular effects]. Exhibiting high specificity for PAR-1 over PAR-2, its selectivity was assessed via cell-based calcium signaling assays in HEK293 cells. As an agonist, it is instrumental for in vivo investigations of PAR-1 activation. PAR-1 also collaborates with PAR-4, influencing thrombin-induced hepatocellular carcinoma within [coagulation type] tumor environments where thrombin generation occurs.

N3-D-Orn(Boc)-OH (CHA) is a Boc-protected derivative of the pentanoic amino acid used in click chemistry and the synthesis of antibody-drug conjugates (ADC) [1].

N3-L-Val-OH (CHA) is an azido-functionalized click chemistry reagent and a derivative of valine. Additionally, N3-L-Val-OH (CHA) serves as a synthetic intermediate for Valaciclovir (Valacyclovir).

Boc-L-Aza-OH CHA is a click chemistry reagent featuring an azido group.

Boc-L-Lys(N3)-OH CHA is a chemical reagent characterized by the presence of an azide group.

Boc-D-Aza-OH (CHA) serves as a click chemistry reagent, extensively utilized for linking nucleic acids, lipids, proteins, and other molecules. Click chemistry is recognized for its high yield, specificity, and simplicity, making it highly advantageous in various research fields.

N3-L-Cys(Trt)-OH (CHA) is a click chemistry reagent featuring an azide group.

Azido-PEG2-CH2COOH (CHA) is an azide-modified PEG2 acid utilized as a click chemistry reagent.

Boc-D-Orn(N3)-OH (CHA) is a click chemistry reagent that includes an azido group.

Boc-D-Lys(N3)-OH CHA is a chemical click reagent featuring an azido group. Click chemistry, known for its high yield, specificity, and simplicity, holds vast potential for applications in linking nucleic acids, lipids, proteins, and other molecules. This reagent is utilized across various research domains due to these advantageous properties.

N3-D-Orn(Boc)-OH (CHA) is a Boc-protected valine derivative utilized as a click chemistry reagent in the synthesis of antibody-drug conjugates (ADC). It contains an Azide group that can undergo copper-catalyzed Azide-Alkyne Cycloaddition (CuAAc) with molecules containing Alkyne groups. Additionally, it can engage in Strain-Promoted Azide-Alkyne Cycloaddition (SPAAC) with molecules possessing DBCO or BCN groups.

Lipopolysaccharides (LPS), derived from Escherichia coli O55:B5, are essential components of the outer membrane of Gram-negative bacteria. Composed of lipid A, a core oligosaccharide, and an O-specific polysaccharide, LPS exhibits strong immunogenicity. It activates immune cells via the TLR4 receptor, induces chemotactic cell migration and cytokine secretion, and helps maintain the integrity of the bacterial outer membrane, protecting against bile salts and lipid-based antibiotics. LPS is commonly used to establish inflammatory models, including arthritis, chronic obstructive pulmonary disease (COPD), acute respiratory distress syndrome (ARDS), and gastrointestinal disease models.

Calcium channel-modulator-1, a calcium channel-modulator (IC50: 0.8 μM), specializes in blocking aortic constriction.

Chalcone 4 hydrate, an anti-parasite compound, inhibits the growth of Theileria and Babesia.

L-Saccharopine is a product of the breakdown of essential amino acid Lysine.

8-[(2,6-dimethylbenzyl)amino]-2,3-dimethylimidazo[1,2-a]pyridine-6-car is a H+/K+ ATPase inhibitor with IC50 of 0.38μM.