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Fukinolic acid
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Catalog No. TN11420Cas No. 50982-40-6
Fukinolic acid is a benzyl tartaric acid ester and functions as a vasodilator with activity against enterovirus A71 (EV-A71) replication. As a receptor-operated Ca2+ channel (ROC) inhibitor, fukinolic acid impedes the influx of extracellular Ca2+ via norepinephrine-activated ROCs without affecting voltage-dependent Ca2+ channels.
Fukinolic acid
😃Good
Catalog No. TN11420Cas No. 50982-40-6
Fukinolic acid is a benzyl tartaric acid ester and functions as a vasodilator with activity against enterovirus A71 (EV-A71) replication. As a receptor-operated Ca2+ channel (ROC) inhibitor, fukinolic acid impedes the influx of extracellular Ca2+ via norepinephrine-activated ROCs without affecting voltage-dependent Ca2+ channels.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks | 10-14 weeks |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Chemical Properties
| Description | Fukinolic acid is a benzyl tartaric acid ester and functions as a vasodilator with activity against enterovirus A71 (EV-A71) replication. As a receptor-operated Ca2+ channel (ROC) inhibitor, fukinolic acid impedes the influx of extracellular Ca2+ via norepinephrine-activated ROCs without affecting voltage-dependent Ca2+ channels. |
| In vitro | Fukinolic acid at a concentration of 300 μM over 1 hour induces non-endothelium-dependent relaxation in norepinephrine-precontracted rat aortic rings, and it inhibits Ca 2+ influx, reducing norepinephrine-induced contractions. At 4.3 µg/mL over 4 days, it decreases EV71 BrCr virus-induced cytopathic effects by 50%, while at 500 µg/mL, it causes 50% cytotoxicity. Additionally, at concentrations ranging from 0 to 230 µM over 16 hours in COS-1 cells, fukinolic acid does not inhibit EV-A71 3C protease activity. |
| Molecular Weight | 434.35 |
| Formula | C20H18O11 |
| Cas No. | 50982-40-6 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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