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Rilmakalim

🥰Excellent
Catalog No. T26086Cas No. 132014-21-2

Rilmakalim is a potassium channel opener. Rilmakalim shows antivasoconstrictor effect.

Rilmakalim
Other Forms of Rilmakalim:
(Iso)-RilmakalimT26086L184653-89-2
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Rilmakalim

🥰Excellent
Purity: 99.9%
Catalog No. T26086Cas No. 132014-21-2
Rilmakalim is a potassium channel opener. Rilmakalim shows antivasoconstrictor effect.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$130In StockIn Stock
5 mg$320In StockIn Stock
10 mg$480In StockIn Stock
25 mg$786In StockIn Stock
50 mg$1,080In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
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Batch Information

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Purity:99.9%
ee:100%
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Resource Download

COA CSFC HNMR ORP HPLC

Product Introduction

Bioactivity
Description
Rilmakalim is a potassium channel opener. Rilmakalim shows antivasoconstrictor effect.
In vitro
Rilmakalim (ventricular rat myocytes; patch-clamp technique) is a channel opener dose-dependently activated whole-cell currents [concentration for half-maximal activation (EC50) = 1.1 μM, Hill coefficient = 3.1, saturation concentration 10 microM].[2]
Chemical Properties
Molecular Weight401.48
FormulaC21H23NO5S
Cas No.132014-21-2
SmilesO[C@H]1[C@@H](C=2C(=CC=C(S(=O)(=O)C3=CC=CC=C3)C2)OC1(C)C)N4C(=O)CCC4
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 50 mg/mL (124.54 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.4908 mL12.4539 mL24.9078 mL124.5392 mL
5 mM0.4982 mL2.4908 mL4.9816 mL24.9078 mL
10 mM0.2491 mL1.2454 mL2.4908 mL12.4539 mL
20 mM0.1245 mL0.6227 mL1.2454 mL6.2270 mL
50 mM0.0498 mL0.2491 mL0.4982 mL2.4908 mL
100 mM0.0249 mL0.1245 mL0.2491 mL1.2454 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
% DMSO
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Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

SodiumChannelSodium ChannelRilmakalim
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