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Rilmakalim

Name: Rilmakalim
Brand: TargetMol
SKU: T26086
Price: 130 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T26086Cas No. 132014-21-2

Rilmakalim is a potassium channel opener. Rilmakalim shows antivasoconstrictor effect.

Rilmakalim

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🥰Excellent

Purity: 99.9%

Catalog No. T26086Cas No. 132014-21-2

Rilmakalim is a potassium channel opener. Rilmakalim shows antivasoconstrictor effect.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$130	In Stock	In Stock
5 mg	$320	In Stock	In Stock
10 mg	$480	In Stock	In Stock
25 mg	$786	In Stock	In Stock
50 mg	$1,080	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.9%

ee:100%

Appearance:Solid

Color:White

Resource Download

COA CSFC HNMR ORP HPLC

Product Introduction

Bioactivity

Description	Rilmakalim is a potassium channel opener. Rilmakalim shows antivasoconstrictor effect.
In vitro	Rilmakalim (ventricular rat myocytes; patch-clamp technique) is a channel opener dose-dependently activated whole-cell currents [concentration for half-maximal activation (EC50) = 1.1 μM, Hill coefficient = 3.1, saturation concentration 10 microM].[2]

Chemical Properties

Molecular Weight	401.48
Formula	C₂₁H₂₃NO₅S
Cas No.	132014-21-2
Smiles	O[C@H]1[C@@H](C=2C(=CC=C(S(=O)(=O)C3=CC=CC=C3)C2)OC1(C)C)N4C(=O)CCC4

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (124.54 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4908 mL	12.4539 mL	24.9078 mL	124.5392 mL
5 mM	0.4982 mL	2.4908 mL	4.9816 mL	24.9078 mL
10 mM	0.2491 mL	1.2454 mL	2.4908 mL	12.4539 mL
20 mM	0.1245 mL	0.6227 mL	1.2454 mL	6.2270 mL
50 mM	0.0498 mL	0.2491 mL	0.4982 mL	2.4908 mL
100 mM	0.0249 mL	0.1245 mL	0.2491 mL	1.2454 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc