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Methyl 3,4,5-trimethoxycinnamate

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Catalog No. TMA0763 Copy Product Info
Purity: 99.69%
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Methyl 3,4,5-trimethoxycinnamate (MTC) is a bioactive natural phenylpropanoid. Methyl 3,4,5-trimethoxycinnamate (MTC) was evaluated in RAW264.7 macrophages and RAW264.7-3T3-L1 adipocyte co-culture systems using ELISAs, Griess assay, enzyme immunoassays, cytoblot analysis, DNA binding assays, reporter gene assays, and glucose uptake assays to investigate inflammatory and metabolic signaling responses. Methyl 3,4,5-trimethoxycinnamate (MTC) at 5–20 µM suppressed LPS + IFNγ-induced release of TNFα, IL-6 and IL-1β, as well as NO/iNOS and PGE2/COX-2 levels in RAW264.7 cells. Methyl 3,4,5-trimethoxycinnamate (MTC) also reduced phospho-IκB and phospho-p65 protein levels and total IκB levels in RAW264.7 cells, and is therefore used in immunometabolic signaling research to model inflammatory transcriptional regulation in macrophage–adipocyte co-culture systems.
Methyl 3,4,5-trimethoxycinnamate
Cas No. 7560-49-8
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Pack SizePriceUSA StockGlobal StockQuantity
1 mg$88-In Stock
5 mg$218-In Stock
10 mg$348-In Stock
25 mg$689-In Stock
50 mg$973-In Stock
100 mg$1,290-In Stock
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:99.69%
Appearance:Solid
Color:White
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Product Introduction

Bioactivity
Description
Methyl 3,4,5-trimethoxycinnamate (MTC) is a bioactive natural phenylpropanoid. Methyl 3,4,5-trimethoxycinnamate (MTC) was evaluated in RAW264.7 macrophages and RAW264.7-3T3-L1 adipocyte co-culture systems using ELISAs, Griess assay, enzyme immunoassays, cytoblot analysis, DNA binding assays, reporter gene assays, and glucose uptake assays to investigate inflammatory and metabolic signaling responses. Methyl 3,4,5-trimethoxycinnamate (MTC) at 5–20 µM suppressed LPS + IFNγ-induced release of TNFα, IL-6 and IL-1β, as well as NO/iNOS and PGE2/COX-2 levels in RAW264.7 cells. Methyl 3,4,5-trimethoxycinnamate (MTC) also reduced phospho-IκB and phospho-p65 protein levels and total IκB levels in RAW264.7 cells, and is therefore used in immunometabolic signaling research to model inflammatory transcriptional regulation in macrophage–adipocyte co-culture systems.
Chemical Properties
Molecular Weight252.26
FormulaC13H16O5
Cas No.7560-49-8
SmilesO=C(OC)C=CC1=CC(OC)=C(OC)C(OC)=C1
Relative Density.1.134 g/cm3 (Predicted)
Storage & Solubility Information
StorageKeep away from direct sunlight,Keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 µL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
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2 Enter the in vivo formulation:
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Keywords

PotassiumChannelPotassium ChannelMethyl 3,4,5-trimethoxycinnamateMethyl 3,4,5trimethoxycinnamateMethyl 3,4,5 trimethoxycinnamateCalciumChannelCalcium Channel
Related Tags: Methyl 3,4,5-trimethoxycinnamate chemical structure | Methyl 3,4,5-trimethoxycinnamate formula | Methyl 3,4,5-trimethoxycinnamate molecular weight
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