p 3

JK-P3 is a pyrazole-based inhibitor of VEGFR-2 (IC50: 7.8 μM). JK-P3 inhibits FGFR 1/3 kinase activity in vitro, but has no effect on FGFR signaling in cell-based assays. The compound blocks wound healing and tube formation in HUVEC without effecting endo

D-myo-Inositol 1,4,5-trisphosphate hexapotassium salt is a second messenger that promotes the release of calcium ions from the endoplasmic reticulum.

The phosphatidylinositol (PtdIns) phosphates represent a small percentage of total membrane phospholipids. However, they play a critical role in the generation and transmission of cellular signals. PtdIns-(3,4,5)-P3, also known as PIP3, is resistant to cleavage by PI-specific phospholipase C (PLC). Thus, it is likely to function in signal transduction as a modulator in its own right, rather than as a source of inositol tetraphosphates. PIP3 can serve as an anchor for the binding of signal transduction proteins bearing pleckstrin homology (PH) domains. Protein binding to PIP3 is important for cytoskeletal rearrangement and membrane trafficking. PtdIns-(3,4,5)-P3 (1,2-dihexanoyl) is a synthetic analog of natural PIP3 with C6:0 fatty acids at the sn-1 and sn-2 positions. The compound features the same inositol and diacylglycerol (DAG) stereochemistry as that of the natural compound. The short fatty acid chains of this analog give it different physical properties from naturally-occurring PIP3, including higher solubility in aqueous media.

The Anti-CEACAM7 Antibody (P3-7B) is a chimeric monoclonal antibody of the mouse IgG1, κ class, targeting CEACAM7 (human origin). Its isotype control is MouseIgG1kappa, Isotype Control.

18:0-20:4 PI(3,4,5)P3 is a reagent used in biochemical reactions.

18:1 PI(3,4,5)P3 is a reagent used in biochemical reactions.

PtdIns-(3,4,5)-P3 (1,2-dioctanoyl) (DOPI-3,4,5-P3) sodium is an analog of phosphatidylinositol.

18:0-20:4 PI(3,4,5)P3 (sodium) is an analogue of phosphatidylinositol. The interaction between proteins and PtdIns-(3,4,5)-P3 is crucial for cytoskeletal rearrangement and membrane trafficking. Notably, PtdIns-(3,4,5)-P3 is resistant to cleavage by PI-specific PLC.

Ansamitocin P 3' (Maytansinol butyrate) is an antibody-drug conjugate cytotoxin with antitumor activity.

Midecamycin (Medecamycin A1), an acetoxy-substituted macrolide antibiotic, has effective on gram-positive and gram-negative bacteria acts by inhibiting bacterial protein synthesis.

CBP/p300-IN-3 (P300/CBP-IN-3) is an inhibitor of p300/CBP histone acetyltransferase.

p-3-Methylamino propyl phenol is a useful organic compound for research related to life sciences and the catalog number is T125046.

Ansamitocin p-3 (Maytansinol isobutyrate) is an inhibitor of microtubule with IC50 of 3.4 μM for tubulin polymerization.

The phosphatidylinositol phosphates represent a small percentage of total membrane phospholipids. However, they play a critical role in the generation and transmission of cellular signals. PtdIns-(3,4,5)-P3 can serve as an anchor for the binding of signal transduction proteins bearing pleckstrin homology (PH) domains. Centuarin α and the Akt-family of GTPase activating proteins are examples of PtdIns-(3,4,5)-P3-binding proteins. Protein-binding to PtdIns-(3,4,5)-P3 is important for cytoskeletal rearrangements and membrane trafficking. PtdIns-(3,4,5)-P3 is resistant to cleavage by PI-specific phospholipase C (PLC). Thus, it is likely to function in signal transduction as a modulator in its own right, rather than as a source of inositol tetraphosphates. For further reading on inositol phospholipids, see also references and .

The PtdIn phosphates play an important role in the generation and transduction of intracellular signals. PtdIns-(3,4,5)-P3-biotin is an affinity probe which allows the PIP3 to be detected through an interaction with the biotin ligand. This design allows PtdIns-(3,4,5)-P3-biotin to serve as a general probe for any protein with a high affinity binding interaction with inositol-(3,4,5)-triphosphate phospholipids, such as phosphatidylinositol 3-kinase, PTEN, or PH-domain-containing proteins.

Ginsenoside Ro (Chikusetsusaponin V) can reduce TXA2 production, weakly reduce COX-1 and TXAS activities, and has antiplatelet effects as a Ca2+ antagonist with an IC50 of 155 μM.

N-Demethylansamitocin P-3, a derivative of Ansamitocin, an antitumor ansamycin antibiotic, can be synthesized through the action of Streptomyces minutiscleroticus IFO 13361.

Zosuquidar trihydrochloride (LY-335979 trihydrochloride) is a potent modulator of P-glycoprotein-mediated multi-drug resistance with Ki of 60 nM. Phase 3.

D-myo-Inositol-1,2,6-triphosphate (sodium) is part of the inositol phosphate second messenger family and plays a crucial role in cellular signal transduction. Upon binding to receptors on the endoplasmic reticulum, it opens calcium channels, leading to an increase in intracellular calcium ion concentration.

D-myo-Inositol-2,4,5-triphosphate (Ins(2,4,5)P3) (sodium salt) is a second messenger produced by the hydrolysis of phosphatidylinositol-4,5-bisphosphate mediated by phospholipase C. Upon binding to receptors on the endoplasmic reticulum, it can open calcium channels and raise intracellular calcium ion concentrations. It also acts as a partial agonist of rat hepatic IP3 receptors. This compound is utilized in the study of calcium signaling pathways.

D-myo-Inositol-1,3,4-triphosphate (sodium) is one of the inositol polyphosphate isomers involved in signal transduction. It increases intracellular levels of Ins(3,4,5,6)-P4 by inhibiting the activity of Ins(3,4,5,6)-P4 kinase, which in turn suppresses calcium-activated chloride channels. This compound is regulated by cytoplasmic free calcium levels.

D-myo-Inositol-1,4,5-triphosphate tripotassium (Ins(1,4,5)-P3 tripotassium) is a second messenger in cellular signal transduction that triggers Ca2+ mobilization.

D-myo-Inositol-1,4,5-triphosphate trisodium (Inositol 1,4,5-trisphosphate trisodium) is a second messenger produced in cells by the phospholipase C-mediated hydrolysis of phosphatidylinositol-4,5-bisphosphate. It binds to Ins(1,4,5)P3 receptors, resulting in the opening of calcium channels and an increase in intracellular calcium.

p38 MAPK-IN-3 (Compound 2c) is a potent inhibitor of p38α MAPK, exhibiting antitumor properties through the promotion of apoptosis and the enhancement of reactive oxygen species (ROS) production [1].