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INF 195

Name: INF 195
Brand: TargetMol
SKU: T87945
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T87945Cas No. 1211379-56-4

Alias INF-195, INF195

INF 195 is an inflammasome NLRP3 inhibitor that inhibits NLRP3-driven macrophage pyroptosis and IL-1β release. INF 195 reduces isoproterenol-induced hypertrophy in H9c2 rat myoblasts and can be used to study myocardial ischemia and myocardial infarction.

INF 195

🥰Excellent

Purity: 99.78%

Catalog No. T87945Alias INF-195, INF195Cas No. 1211379-56-4

Pack Size	Price	Availability
10 mg	$33	In Stock
25 mg	$68	In Stock
50 mg	$107	In Stock
100 mg	$172	In Stock
200 mg	$255	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock

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Purity:99.78%

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COA HPLC HNMR

Product Introduction

Bioactivity

Description	INF 195 is an inflammasome NLRP3 inhibitor that inhibits NLRP3-driven macrophage pyroptosis and IL-1β release. INF 195 reduces isoproterenol-induced hypertrophy in H9c2 rat myoblasts and can be used to study myocardial ischemia and myocardial infarction.
In vitro	INF 195 (0.1-100 μM, 72 hours) was able to inhibit macrophage pyroptosis and IL-1β release driven by NLRP3. At lower doses (5-10 μM, 10 min), INF 195 was able to reduce the infarct zone in isolated mouse hearts and effectively prevented myocardial ischemia/reperfusion injury.INF 195 (10 μM), as an ethyl ester precursor of the active metabolite 3-(3-(2-chlorophenyl)propanoyl)piperidine-1-carboxylic acid, was able to penetrate into H9c2 cardiomyoblasts, and hydrolyzed intracellularly to this active form. [1]
Synonyms	INF-195, INF195

Chemical Properties

Molecular Weight	323.81
Formula	C₁₇H₂₂ClNO₃
Cas No.	1211379-56-4
Smiles	O=C(OCC)C1CN(C(=O)CCC=2C=CC=CC2Cl)CCC1
Relative Density.	1.190 g/cm3 at 20℃ (Predicted)
Color	Yellow
Appearance	Oil

Storage & Solubility Information

Storage

store at low temperature | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 150 mg/mL (463.23 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0882 mL	15.4412 mL	30.8823 mL	154.4115 mL
5 mM	0.6176 mL	3.0882 mL	6.1765 mL	30.8823 mL
10 mM	0.3088 mL	1.5441 mL	3.0882 mL	15.4412 mL
20 mM	0.1544 mL	0.7721 mL	1.5441 mL	7.7206 mL
50 mM	0.0618 mL	0.3088 mL	0.6176 mL	3.0882 mL
100 mM	0.0309 mL	0.1544 mL	0.3088 mL	1.5441 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc