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INF 195

Name: INF 195
Brand: TargetMol
SKU: T87945
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T87945Cas No. 1211379-56-4

Alias INF-195, INF195

INF 195 is an inflammasome NLRP3 inhibitor that inhibits NLRP3-driven macrophage pyroptosis and IL-1β release. INF 195 reduces isoproterenol-induced hypertrophy in H9c2 rat myoblasts and can be used to study myocardial ischemia and myocardial infarction.

INF 195

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Purity: 99.78%

Catalog No. T87945Alias INF-195, INF195Cas No. 1211379-56-4

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$31	-	In Stock
25 mg	$64	-	In Stock
50 mg	$98	-	In Stock
100 mg	$163	-	In Stock
1 mL x 10 mM (in DMSO)	$29	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.78%

Appearance:Oil

Color:Yellow

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COA HPLC HNMR

Product Introduction

Bioactivity

Description	INF 195 is an inflammasome NLRP3 inhibitor that inhibits NLRP3-driven macrophage pyroptosis and IL-1β release. INF 195 reduces isoproterenol-induced hypertrophy in H9c2 rat myoblasts and can be used to study myocardial ischemia and myocardial infarction.
In vitro	INF 195 (0.1-100 μM, 72 hours) was able to inhibit macrophage pyroptosis and IL-1β release driven by NLRP3. At lower doses (5-10 μM, 10 min), INF 195 was able to reduce the infarct zone in isolated mouse hearts and effectively prevented myocardial ischemia/reperfusion injury.INF 195 (10 μM), as an ethyl ester precursor of the active metabolite 3-(3-(2-chlorophenyl)propanoyl)piperidine-1-carboxylic acid, was able to penetrate into H9c2 cardiomyoblasts, and hydrolyzed intracellularly to this active form. [1]
Synonyms	INF-195, INF195

Chemical Properties

Molecular Weight	323.81
Formula	C₁₇H₂₂ClNO₃
Cas No.	1211379-56-4
Smiles	O=C(OCC)C1CN(C(=O)CCC=2C=CC=CC2Cl)CCC1
Relative Density.	1.190 g/cm3 at 20℃ (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 150 mg/mL (463.23 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0882 mL	15.4412 mL	30.8823 mL	154.4115 mL
5 mM	0.6176 mL	3.0882 mL	6.1765 mL	30.8823 mL
10 mM	0.3088 mL	1.5441 mL	3.0882 mL	15.4412 mL
20 mM	0.1544 mL	0.7721 mL	1.5441 mL	7.7206 mL
50 mM	0.0618 mL	0.3088 mL	0.6176 mL	3.0882 mL
100 mM	0.0309 mL	0.1544 mL	0.3088 mL	1.5441 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc