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Thr-Leu

Name: Thr-Leu
Brand: TargetMol
SKU: TP3965
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TP3965Cas No. 50299-12-2

Alias Thr-Leu, L-Threonyl-L-leucine, H-Thr-Leu-OH

Thr-Leu is a dipeptide composed of threonine and leucine that can be hydrolyzed in the peritoneal cavity to release its constituent amino acids, thereby increasing dialysate osmotic pressure, and it is used in kinetic and formulation studies of amino acid–based peritoneal dialysis fluids.

Thr-Leu

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Purity: 99.73%

Catalog No. TP3965Alias Thr-Leu, L-Threonyl-L-leucine, H-Thr-Leu-OHCas No. 50299-12-2

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$29	-	In Stock
5 mg	$47	-	In Stock
10 mg	$66	-	In Stock
25 mg	$113	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.73%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Thr-Leu is a dipeptide composed of threonine and leucine that can be hydrolyzed in the peritoneal cavity to release its constituent amino acids, thereby increasing dialysate osmotic pressure, and it is used in kinetic and formulation studies of amino acid–based peritoneal dialysis fluids.
In vitro	Method: Four-hour peritoneal dwell studies in rats were performed using Thr-Leu dipeptide solutions at 8 or 16 mmol/L and compared with a 1.1% amino acid solution, with kinetic modeling of hydrolysis and transport. Result: Dipeptide solutions showed slower peritoneal volume reduction than amino acid solution, with hydrolysis rates independent of concentration and diffusive transport rates exceeding hydrolysis rates[1].
Synonyms	Thr-Leu, L-Threonyl-L-leucine, H-Thr-Leu-OH

Chemical Properties

Molecular Weight	232.28
Formula	C₁₀H₂₀N₂O₄
Cas No.	50299-12-2
Smiles	[C@H](NC([C@H]([C@@H](C)O)N)=O)(CC(C)C)C(O)=O
Color	White
Appearance	Solid
Sequence	H-Thr-Leu-OH
Sequence Short	TL

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 100 mg/mL (430.51 mM), Sonication is recommended.

DMSO: 100 mg/mL (430.51 mM), Sonication is recommended.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	4.3051 mL	21.5257 mL	43.0515 mL	215.2574 mL
5 mM	0.8610 mL	4.3051 mL	8.6103 mL	43.0515 mL
10 mM	0.4305 mL	2.1526 mL	4.3051 mL	21.5257 mL
20 mM	0.2153 mL	1.0763 mL	2.1526 mL	10.7629 mL
50 mM	0.0861 mL	0.4305 mL	0.8610 mL	4.3051 mL
100 mM	0.0431 mL	0.2153 mL	0.4305 mL	2.1526 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline /PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Stock solution preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(stock solution concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline /PBS/ddH₂O TargetMol | reagent

mix well and clarify

The above example illustrates how to use "In Vivo Formulation Calculator" and does not represent a recommended formulation for any specific compound. Please select an appropriate dissolution method based on your experimental animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

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