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Sebrinoflast
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Catalog No. T212016Cas No. 2919854-67-2
Sebrinoflast (Compound 5) is an NLRP3 inhibitor with an IC50 for hNLRP3 of ≤1 μM. It is utilized in the research of inflammatory and cardiovascular conditions (such as NASH and atherosclerosis), as well as neurological disorders (including Alzheimer's disease).
Sebrinoflast
🥰Excellent
Catalog No. T212016Cas No. 2919854-67-2
Sebrinoflast (Compound 5) is an NLRP3 inhibitor with an IC50 for hNLRP3 of ≤1 μM. It is utilized in the research of inflammatory and cardiovascular conditions (such as NASH and atherosclerosis), as well as neurological disorders (including Alzheimer's disease).
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Product Introduction
Bioactivity
Chemical Properties
| Description | Sebrinoflast (Compound 5) is an NLRP3 inhibitor with an IC50 for hNLRP3 of ≤1 μM. It is utilized in the research of inflammatory and cardiovascular conditions (such as NASH and atherosclerosis), as well as neurological disorders (including Alzheimer's disease). |
| Targets&IC50 | NLRP3:≤1 μM |
| Molecular Weight | 350.41 |
| Formula | C20H22N4O2 |
| Cas No. | 2919854-67-2 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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