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MAIT-203 acetate

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Catalog No. TP3070

MAIT-203 acetate is a cyclopentylglycine-derived peptidomimetic that effectively inhibits the interaction between adenomatous polyposis coli (APC) and Asef (RhoGEF4), while not affecting the APC-Sam68 or APC-striatin interactions. It binds to APC-ARM with a Ki of 0.015 μM and a Kd of 0.036 μM, significantly impeding the migration and invasion of colorectal cancer cells.

MAIT-203 acetate
Other Forms of MAIT-203 acetate:

MAIT-203 acetate

😃Good
Catalog No. TP3070
MAIT-203 acetate is a cyclopentylglycine-derived peptidomimetic that effectively inhibits the interaction between adenomatous polyposis coli (APC) and Asef (RhoGEF4), while not affecting the APC-Sam68 or APC-striatin interactions. It binds to APC-ARM with a Ki of 0.015 μM and a Kd of 0.036 μM, significantly impeding the migration and invasion of colorectal cancer cells.
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1 mg$987-10 days
5 mgPreferential7-10 days
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Product Introduction

Bioactivity
Description
MAIT-203 acetate is a cyclopentylglycine-derived peptidomimetic that effectively inhibits the interaction between adenomatous polyposis coli (APC) and Asef (RhoGEF4), while not affecting the APC-Sam68 or APC-striatin interactions. It binds to APC-ARM with a Ki of 0.015 μM and a Kd of 0.036 μM, significantly impeding the migration and invasion of colorectal cancer cells.
In vitro
MAIT-203 (10 μM and 25 μM; for 24 h) acetate reduces the interaction between Asef and APC in a dose-dependent manner in HEK293T cells [1]. Additionally, MAIT-203 (10 μM) acetate significantly reduces the migration of SW480 and HCT116 cells [1]. Incubating SW480 cells with MAIT-203 (25, 50 μM; 24 hours) acetate leads to a dose-dependent decrease in the active form of CDC42, while Rac1 remains unaffected [1].
Chemical Properties
Molecular Weight2517.85 (free base)
FormulaC108H121N43O31
Storage & Solubility Information
Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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