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MAIT-203 acetate is a cyclopentylglycine-derived peptidomimetic that effectively inhibits the interaction between adenomatous polyposis coli (APC) and Asef (RhoGEF4), while not affecting the APC-Sam68 or APC-striatin interactions. It binds to APC-ARM with a Ki of 0.015 μM and a Kd of 0.036 μM, significantly impeding the migration and invasion of colorectal cancer cells.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $98 | 7-10 days | |
5 mg | Preferential | 7-10 days |
Description | MAIT-203 acetate is a cyclopentylglycine-derived peptidomimetic that effectively inhibits the interaction between adenomatous polyposis coli (APC) and Asef (RhoGEF4), while not affecting the APC-Sam68 or APC-striatin interactions. It binds to APC-ARM with a Ki of 0.015 μM and a Kd of 0.036 μM, significantly impeding the migration and invasion of colorectal cancer cells. |
In vitro | MAIT-203 (10 μM and 25 μM; for 24 h) acetate reduces the interaction between Asef and APC in a dose-dependent manner in HEK293T cells [1]. Additionally, MAIT-203 (10 μM) acetate significantly reduces the migration of SW480 and HCT116 cells [1]. Incubating SW480 cells with MAIT-203 (25, 50 μM; 24 hours) acetate leads to a dose-dependent decrease in the active form of CDC42, while Rac1 remains unaffected [1]. |
Molecular Weight | 2517.85 (free base) |
Formula | C108H121N43O31 |
Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice./Shipping at ambient temperature. |
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