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antcin A

Name: antcin A
Brand: TargetMol
SKU: TN7099
Price: 228 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TN7099Cas No. 163597-24-8

antcin A is a steroid-like phytochemical isolated from the fruiting bodies of a precious edible mushroom Antrodia cinnamomea with strong anti-inflammatory and anti-tumor effects.

antcin A

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Purity: 96.43%

Catalog No. TN7099Cas No. 163597-24-8

antcin A is a steroid-like phytochemical isolated from the fruiting bodies of a precious edible mushroom Antrodia cinnamomea with strong anti-inflammatory and anti-tumor effects.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$228	-	In Stock
2 mg	$383	-	In Stock
5 mg	$723	-	In Stock
10 mg	$998	-	In Stock
1 mL x 10 mM (in DMSO)	$786	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:96.43%

Appearance:Solid

Color:White

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COA

Product Introduction

Bioactivity

Description	antcin A is a steroid-like phytochemical isolated from the fruiting bodies of a precious edible mushroom Antrodia cinnamomea with strong anti-inflammatory and anti-tumor effects.
In vitro	Antcin A could significantly inhibit the occurrence of pyrolysis, decrease the expression of inflammatory factors, inhibit the activation and assembly of NLRP3 inflammasome, and significantly down-regulate the expression of NLRP3, Caspase-1 and GSDMD-NT in KCs[1].
In vivo	In NAFLD mice, Antcin A could suppress the inflammatory response in liver tissues of mice, reduce lipid deposition, down-regulate the levels of ALT and AST, and improve liver function in mice. Antcin A could also inhibit the activation of NLRP3 inflammasome in liver tissue and decrease the level of inflammatory factors[1].

Chemical Properties

Molecular Weight	454.64
Formula	C₂₉H₄₂O₄
Cas No.	163597-24-8
Smiles	C[C@@]12C3=C([C@]4([C@](C)(CC3=O)[C@@]([C@@H](CCC(C(C(O)=O)C)=C)C)(CC4)[H])[H])CC[C@]1([C@H](C)C(=O)CC2)[H]
Relative Density.	1.11 g/cm3 (Predicted)

Storage & Solubility Information

Storage

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (109.98 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1995 mL	10.9977 mL	21.9954 mL	109.9771 mL
5 mM	0.4399 mL	2.1995 mL	4.3991 mL	21.9954 mL
10 mM	0.2200 mL	1.0998 mL	2.1995 mL	10.9977 mL
20 mM	0.1100 mL	0.5499 mL	1.0998 mL	5.4989 mL
50 mM	0.0440 mL	0.2200 mL	0.4399 mL	2.1995 mL
100 mM	0.0220 mL	0.1100 mL	0.2200 mL	1.0998 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc