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LNSMGQD is a peptide that targets the adhesive interfaces of desmoglein (DSG1 and DSG3) core glycoproteins, interfering with the single peptide (SP) components of DSG trans-interactions. By binding to DSGs, LNSMGQD prevents the loss of DSG trans-interactions induced by autoantibodies, inhibits the activation of p38 MAPK, and prevents keratin filament retraction. It is useful for research into autoimmune skin diseases such as pemphigus vulgaris.

| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks | 10-14 weeks |
| Description | LNSMGQD is a peptide that targets the adhesive interfaces of desmoglein (DSG1 and DSG3) core glycoproteins, interfering with the single peptide (SP) components of DSG trans-interactions. By binding to DSGs, LNSMGQD prevents the loss of DSG trans-interactions induced by autoantibodies, inhibits the activation of p38 MAPK, and prevents keratin filament retraction. It is useful for research into autoimmune skin diseases such as pemphigus vulgaris. |
| Molecular Weight | 763.82 |
| Formula | C29H49N9O13S |
| Cas No. | 1152066-26-6 |
| Smiles | [C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@@H](CC(O)=O)C(O)=O)=O)CCC(N)=O)=O)=O)CCSC)=O)CO)=O)(NC([C@H](CC(C)C)N)=O)CC(N)=O |
| Sequence | Leu-Asn-Ser-Met-Gly-Gln-Asp |
| Sequence Short | LNSMGQD |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
Dissolve 2 mg of the compound in 100 μL DMSO
to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
1) Add 100 μL of the DMSO
stock solution to 400 μL PEG300
and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O
and mix thoroughly until a homogeneous solution is obtained.
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