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Insulin degludec
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Catalog No. T72656Cas No. 844439-96-9
Insulin degludec is an ultra-long-acting insulin analog developed for the study of hyperglycemia associated with type 1 and type 2 diabetes. Insulin degludec exhibits binding efficiency to the insulin receptor with an IC50 of 19.59 nM. Insulin degludec is applicable in diabetes research for evaluating pharmacological properties of basal insulin therapies.
Insulin degludec
Insulin degludec
😃Good
Catalog No. T72656Cas No. 844439-96-9
Insulin degludec is an ultra-long-acting insulin analog developed for the study of hyperglycemia associated with type 1 and type 2 diabetes. Insulin degludec exhibits binding efficiency to the insulin receptor with an IC50 of 19.59 nM. Insulin degludec is applicable in diabetes research for evaluating pharmacological properties of basal insulin therapies.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $74 | - | In Stock | |
| 5 mg | $179 | - | In Stock | |
| 10 mg | $289 | - | In Stock | |
| 25 mg | $579 | - | In Stock | |
| 50 mg | $892 | - | In Stock | |
| 100 mg | $1,360 | - | In Stock | |
| 200 mg | $1,830 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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| Description | Insulin degludec is an ultra-long-acting insulin analog developed for the study of hyperglycemia associated with type 1 and type 2 diabetes. Insulin degludec exhibits binding efficiency to the insulin receptor with an IC50 of 19.59 nM. Insulin degludec is applicable in diabetes research for evaluating pharmacological properties of basal insulin therapies. |
| Targets&IC50 | insulin receptor:19.59 nM |
| In vitro | Methods: HL-1 cardiomyocytes were treated with Insulin degludec (200 nM, 0-60 min), and the phosphorylation level of Akt was detected by Western blot. Results: The phosphorylation level of Akt decreased after 5 and 10 minutes of Insulin degludec treatment. [2] |
| In vivo | Methods: Insulin degludec (5 U/kg, once daily for 30 consecutive days) was subcutaneously administered to diabetes mellitus mice to investigate the effects of Insulin degludec on vitis vinifera glucose homeostasis and hepatic metabolism in T1D mice under IIH conditions. Results: Insulin degludec significantly improved utetheisa kong fasting blood glucose, body weight gain, and serum AST and ALT activities in T1D mice, but exhibited a weaker response to IIH.[1] |
| Molecular Weight | 6103.97 |
| Formula | C274H411N65O81S6 |
| Cas No. | 844439-96-9 |
| Storage | keep away from moisture,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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