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Apelin biased agonist; exhibits bias for the G protein pathway. Stimulates endothelial NOS phosphorylation and expression, promotes proliferation, and attenuates apoptosis of human pulmonary arterial endothelial cells in vitro. Shows positive inotropic and vasodilatory effects in vivo and improves cardiac structure and function in a model of pulmonary arterial hypertension.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $150 | Backorder |
Description | Apelin biased agonist; exhibits bias for the G protein pathway. Stimulates endothelial NOS phosphorylation and expression, promotes proliferation, and attenuates apoptosis of human pulmonary arterial endothelial cells in vitro. Shows positive inotropic and vasodilatory effects in vivo and improves cardiac structure and function in a model of pulmonary arterial hypertension. |
Molecular Weight | 1539.9 |
Formula | C67H106N22O14S3 |
Cas No. | 1876450-21-3 |
Relative Density. | 1.52 g/cm3 (Predicted) |
Sequence | Cys-Arg-Pro-Arg-Leu-Cys-His-Lys-Gly-Pro-Met-Pro-Phe (Disulfide bridge:Cys1-Cys6) |
Sequence Short | CRPRLCHKGPMPF (Disulfide bridge:Cys1-Cys6) |
Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||
Solubility Information | H2O: 2 mg/mL (1.3 mM), Sonication is recommended. | ||||||||||
Solution Preparation Table | |||||||||||
H2O
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