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Pravastatin lactone

Name: Pravastatin lactone
Brand: TargetMol
SKU: T37642
Rating: 4.5 (1 reviews)

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Catalog No. T37642Cas No. 85956-22-5

Pravastatin lactone is a metabolite of pravastatin , a hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor that is a ring-hydroxylated metabolite of mevastatin . Pravastatin lactone is formed when pravastatin undergoes acid-catalyzed non-enzymatic lactonization in the stomach following oral administration.

Pravastatin lactone

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Catalog No. T37642Cas No. 85956-22-5

Pack Size	Price	Availability	Quantity
5 mg	$273	7-10 days
10 mg	$396	7-10 days

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Product Introduction

Bioactivity

Description

Chemical Properties

Molecular Weight	406.519
Formula	C₂₃H₃₄O₆
Cas No.	85956-22-5

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 20 mg/mL (49.2 mM), Sonication is recommended.

DMF: 25 mg/mL (61.5 mM), Sonication is recommended.

PBS (pH 7.2): 10 mg/mL (24.6 mM), Sonication is recommended.

Ethanol: 12.5 mg/mL (30.75 mM), Sonication is recommended.

Solution Preparation Table

PBS (pH 7.2)/Ethanol/DMSO/DMF

	1mg	5mg	10mg	50mg
1 mM	2.4599 mL	12.2995 mL	24.5991 mL	122.9955 mL
5 mM	0.4920 mL	2.4599 mL	4.9198 mL	24.5991 mL
10 mM	0.2460 mL	1.2300 mL	2.4599 mL	12.2995 mL
20 mM	0.1230 mL	0.6150 mL	1.2300 mL	6.1498 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc