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Carboxy-PTIO potassium

Name: Carboxy-PTIO potassium
Brand: TargetMol
SKU: T22623
Price: 50 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T22623Cas No. 148819-94-7

Alias cPTIO potassium

Carboxy-PTIO potassium (cPTIO potassium) is a nitric oxide (NO) scavenger in endothelial cells, inhibiting pterin accumulation and exhibiting neuroprotective activity. It reacts rapidly with NO to produce NO2.

Carboxy-PTIO potassium

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Purity: 98.14%

Catalog No. T22623Alias cPTIO potassiumCas No. 148819-94-7

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$50	-	In Stock
5 mg	$81	-	In Stock
10 mg	$129	-	In Stock
25 mg	$269	-	In Stock
50 mg	$398	-	In Stock
100 mg	$592	-	In Stock
1 mL x 10 mM (in DMSO)	$89	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.14%

Appearance:Solid

Color:Cyan to Blue

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COA LCMS

Product Introduction

Bioactivity

Description	Carboxy-PTIO potassium (cPTIO potassium) is a nitric oxide (NO) scavenger in endothelial cells, inhibiting pterin accumulation and exhibiting neuroprotective activity. It reacts rapidly with NO to produce NO2.
In vitro	In A375-S2 cells, Carboxy-PTIO potassium (200 μM, 1 h before Physalin A，24 h) reverses Physalin A-induced reduction in mTOR and p-mTOR levels, while inhibiting the conversion of LC3I to LC3II in A375-S2 cells. [1]
In vivo	Carboxy-PTIO potassium (0.056-1.70 mg/kg/min, intravenous) treatment improved hypotension, renal dysfunction, and survival in LPS-treated rats. Carboxy-PTIO potassium did not affect the parameters of normal mice. [2]
Synonyms	cPTIO potassium

Chemical Properties

Molecular Weight	315.39
Formula	C₁₄H₁₆KN₂O₄
Cas No.	148819-94-7
Smiles	[O-]C(C1=CC=C(C(N([O])C(C)(C)C2(C)C)=N2=O)C=C1)=O.[K+]
Relative Density.	no data available

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 8 mg/mL (25.37 mM), Sonication is recommended.

H2O: Soluble

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1707 mL	15.8534 mL	31.7068 mL	158.5339 mL
5 mM	0.6341 mL	3.1707 mL	6.3414 mL	31.7068 mL
10 mM	0.3171 mL	1.5853 mL	3.1707 mL	15.8534 mL
20 mM	0.1585 mL	0.7927 mL	1.5853 mL	7.9267 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc