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Carboxy-PTIO potassium

Name: Carboxy-PTIO potassium
Brand: TargetMol
SKU: T22623
Price: 69 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T22623Cas No. 148819-94-7

Alias cPTIO potassium

Carboxy-PTIO potassium (cPTIO potassium) is a nitric oxide (NO) scavenger in endothelial cells, inhibiting pterin accumulation and exhibiting neuroprotective activity. It reacts rapidly with NO to produce NO2.

Carboxy-PTIO potassium

🥰Excellent

Catalog No. T22623Alias cPTIO potassiumCas No. 148819-94-7

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
2 mg	$69	-	In Stock

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Product Introduction

Bioactivity

Description	Carboxy-PTIO potassium (cPTIO potassium) is a nitric oxide (NO) scavenger in endothelial cells, inhibiting pterin accumulation and exhibiting neuroprotective activity. It reacts rapidly with NO to produce NO2.
In vitro	In A375-S2 cells, Carboxy-PTIO potassium (200 μM, 1 h before Physalin A，24 h) reverses Physalin A-induced reduction in mTOR and p-mTOR levels, while inhibiting the conversion of LC3I to LC3II in A375-S2 cells. [1]
In vivo	Carboxy-PTIO potassium (0.056-1.70 mg/kg/min, intravenous) treatment improved hypotension, renal dysfunction, and survival in LPS-treated rats. Carboxy-PTIO potassium did not affect the parameters of normal mice. [2]
Synonyms	cPTIO potassium

Chemical Properties

Molecular Weight	315.39
Formula	C₁₄H₁₆KN₂O₄
Cas No.	148819-94-7
Smiles	[O-]C(C1=CC=C(C(N([O])C(C)(C)C2(C)C)=N2=O)C=C1)=O.[K+]
Relative Density.	no data available
Color	Blue
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 8.00 mg/mL (25.37 mM), Sonication is recommended.

H2O: Soluble

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1707 mL	15.8534 mL	31.7068 mL	158.5339 mL
5 mM	0.6341 mL	3.1707 mL	6.3414 mL	31.7068 mL
10 mM	0.3171 mL	1.5853 mL	3.1707 mL	15.8534 mL
20 mM	0.1585 mL	0.7927 mL	1.5853 mL	7.9267 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc