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Secoisolariciresinol diglucoside
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Catalog No. T3415Cas No. 158932-33-3
Alias LGM2605
Secoisolariciresinol diglucoside (LGM2605) was cytoprotective in an in vitro model of iron overload-induced redox-inflammatory damage. Secoisolariciresinol diglucoside (25 mg/kg b.w.) exerts the antihyperglycemic effect by preventing the liver from peroxidation damage through inhibition of ROS level mediated increased level of enzymatic and non-enzymatic antioxidants.
Secoisolariciresinol diglucoside
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Purity: 99.98%
Catalog No. T3415Alias LGM2605Cas No. 158932-33-3
Secoisolariciresinol diglucoside (LGM2605) was cytoprotective in an in vitro model of iron overload-induced redox-inflammatory damage. Secoisolariciresinol diglucoside (25 mg/kg b.w.) exerts the antihyperglycemic effect by preventing the liver from peroxidation damage through inhibition of ROS level mediated increased level of enzymatic and non-enzymatic antioxidants.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 5 mg | $39 | In Stock | In Stock | |
| 10 mg | $64 | In Stock | In Stock | |
| 25 mg | $105 | In Stock | In Stock | |
| 50 mg | $169 | In Stock | In Stock | |
| 100 mg | $253 | In Stock | In Stock | |
| 500 mg | $528 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.98%
Color:White
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Product Introduction
Secoisolariciresinol diglucoside AI Summary
Secoisolariciresinol diglucoside exhibits significant antioxidant activity, as demonstrated through various assays, including reduction of K3FeCN6, DPPH radical scavenging, peroxyl radical scavenging, and hydroxyl radical scavenging activities, with EC50 values indicating high efficiency. It shows comparable antioxidant effects to alpha-tocopherol and ascorbic acid, as well as trolox and gallic acid in specific assays. The compound also displays high stability in HBSS after 48 hours (>95.0%) and very low drug metabolism (<3.0%) in human Caco2 cells over 48 hours.
In terms of antiviral properties, Secoisolariciresinol diglucoside inhibits SARS-CoV-2 induced cytotoxicity in Caco-2 and VERO-6 cells at 10 µM concentration after 48 hours, with inhibition rates of -2.73% and -0.11%, respectively. It also inhibits the SARS-CoV-2 3CL-Pro protease by 23.53% at 20 µM concentration, highlighting its potential as an anti-viral agent. Additionally, the compound exhibits inhibitory activity against the human HDAC6 enzyme, with inhibition rates of 29.39% using a commercial peptide substrate and 3.26% with a custom peptide substrate. Overall, Secoisolariciresinol diglucoside presents significant bioactivity as an antioxidant and demonstrates promising anti-viral and enzymatic inhibitory properties..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Secoisolariciresinol diglucoside (LGM2605) was cytoprotective in an in vitro model of iron overload-induced redox-inflammatory damage. Secoisolariciresinol diglucoside (25 mg/kg b.w.) exerts the antihyperglycemic effect by preventing the liver from peroxidation damage through inhibition of ROS level mediated increased level of enzymatic and non-enzymatic antioxidants. |
| Synonyms | LGM2605 |
| Molecular Weight | 686.70 |
| Formula | C32H46O16 |
| Cas No. | 158932-33-3 |
| Smiles | COc1cc(C[C@@H](CO[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)[C@H](CO[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)Cc2ccc(O)c(OC)c2)ccc1O |
| Relative Density. | 1.52 g/cm3 (Predicted) |
| Storage | keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||||||||||||
| Solubility Information | Ethanol: 91.00 mg/mL (132.52 mM), Sonication is recommended. DMSO: 125.00 mg/mL (182.03 mM), Sonication is recommended.  Pyridine, Methanol: Soluble H2O: 50.00 mg/mL (72.81 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4.00 mg/mL (5.82 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
H2O/Ethanol/DMSO
Ethanol/DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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