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CGP 53353

Name: CGP 53353
Brand: TargetMol
SKU: T22650
Price: 129 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T22650Cas No. 145915-60-2

Alias DAPH-7

CGP 53353 (DAPH-7) is a PKC inhibitor with inhibitory effects on PKCβII and PKCβI and can be used to study atherosclerosis.

CGP 53353

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Purity: 98.11%

Catalog No. T22650Alias DAPH-7Cas No. 145915-60-2

CGP 53353 (DAPH-7) is a PKC inhibitor with inhibitory effects on PKCβII and PKCβI and can be used to study atherosclerosis.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$129	-	In Stock
10 mg	$198	-	In Stock
25 mg	$455	-	In Stock
50 mg	$787	-	In Stock
100 mg	$1,280	-	In Stock
1 mL x 10 mM (in DMSO)	$143	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98.11%

Appearance:Solid

Color:Orange

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	CGP 53353 (DAPH-7) is a PKC inhibitor with inhibitory effects on PKCβII and PKCβI and can be used to study atherosclerosis.
Targets&IC50	PKCβII:0.41 mM, PKCβI:3.8 mM
In vitro	In A10 cells, CGP-53353 (DAPH-7) inhibits glucose-induced cell proliferation when administered at 1 μM for 48-96 hours[1]. At a concentration of 1 μM for the initial 0-48 hours, CGP-53353 inhibits the glucose-induced increase and acceleration of DNA synthesis in A10 cells. It also blocks the glucose-induced increase in the percentage of S-phase cells[1].
Synonyms	DAPH-7

Chemical Properties

Molecular Weight	365.33
Formula	C₂₀H₁₃F₂N₃O₂
Cas No.	145915-60-2
Smiles	Fc1ccc(Nc2cc3C(=O)NC(=O)c3cc2Nc2ccc(F)cc2)cc1
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: < 7.31 mg/mL, Sonication is recommended.

DMSO: 50 mg/mL (136.86 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7373 mL	13.6863 mL	27.3725 mL	136.8626 mL
5 mM	0.5475 mL	2.7373 mL	5.4745 mL	27.3725 mL
10 mM	0.2737 mL	1.3686 mL	2.7373 mL	13.6863 mL
20 mM	0.1369 mL	0.6843 mL	1.3686 mL	6.8431 mL
50 mM	0.0547 mL	0.2737 mL	0.5475 mL	2.7373 mL
100 mM	0.0274 mL	0.1369 mL	0.2737 mL	1.3686 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc