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CGP 53353

Name: CGP 53353
Brand: TargetMol
SKU: T22650
Price: 129 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T22650Cas No. 145915-60-2

Alias DAPH-7

CGP 53353 (DAPH-7) is a PKC inhibitor with inhibitory effects on PKCβII and PKCβI and can be used to study atherosclerosis.

CGP 53353

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Purity: 98.11%

Catalog No. T22650Alias DAPH-7Cas No. 145915-60-2

CGP 53353 (DAPH-7) is a PKC inhibitor with inhibitory effects on PKCβII and PKCβI and can be used to study atherosclerosis.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$129	-	In Stock
10 mg	$198	-	In Stock
25 mg	$455	-	In Stock
50 mg	$787	-	In Stock
100 mg	$1,280	-	In Stock
1 mL x 10 mM (in DMSO)	$143	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:98.11%

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	CGP 53353 (DAPH-7) is a PKC inhibitor with inhibitory effects on PKCβII and PKCβI and can be used to study atherosclerosis.
Targets&IC50	PKCβI:3.8 mM, PKCβII:0.41 mM
In vitro	In A10 cells, CGP-53353 (DAPH-7) inhibits glucose-induced cell proliferation when administered at 1 μM for 48-96 hours[1]. At a concentration of 1 μM for the initial 0-48 hours, CGP-53353 inhibits the glucose-induced increase and acceleration of DNA synthesis in A10 cells. It also blocks the glucose-induced increase in the percentage of S-phase cells[1].
Synonyms	DAPH-7

Chemical Properties

Molecular Weight	365.33
Formula	C₂₀H₁₃F₂N₃O₂
Cas No.	145915-60-2
Smiles	Fc1ccc(Nc2cc3C(=O)NC(=O)c3cc2Nc2ccc(F)cc2)cc1
Relative Density.	1.31g/cm3
Color	Orange
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: < 7.31 mg/mL, Sonication is recommended.

DMSO: 50 mg/mL (136.86 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7373 mL	13.6863 mL	27.3725 mL	136.8626 mL
5 mM	0.5475 mL	2.7373 mL	5.4745 mL	27.3725 mL
10 mM	0.2737 mL	1.3686 mL	2.7373 mL	13.6863 mL
20 mM	0.1369 mL	0.6843 mL	1.3686 mL	6.8431 mL
50 mM	0.0547 mL	0.2737 mL	0.5475 mL	2.7373 mL
100 mM	0.0274 mL	0.1369 mL	0.2737 mL	1.3686 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc