AE-3763

Name: AE-3763
Brand: TargetMol
SKU: T10254
Rating: 4.5 (1 reviews)

😃Good

Catalog No. T10254Cas No. 291778-77-3

AE-3763 is a peptide-based inhibitor of human neutrophil elastase with an IC50 of 29 nM.

AE-3763

😃Good

Catalog No. T10254Cas No. 291778-77-3

AE-3763 is a peptide-based inhibitor of human neutrophil elastase with an IC50 of 29 nM.

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	Inquiry	3-6 months	3-6 months
50 mg	Inquiry	3-6 months	3-6 months
100 mg	Inquiry	3-6 months	3-6 months

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Resource Download

Product Introduction

Bioactivity

Description	AE-3763 is a peptide-based inhibitor of human neutrophil elastase with an IC50 of 29 nM.
Targets&IC50	Neutrophil elastase (human):29 nM
In vitro	AE-3763 has potent inhibitory activity against human neutrophil elastase as well as extremely high solubility and stability in water.
In vivo	The infusion of AE-3763 significantly inhibits edema and leukocyte infiltration into the lung and improves the survival rate by 24 hours in a mouse model of fatal shock with multiple organ dysfunction. AE-3763 dose-dependently prevents hemorrhage when administered intravenously by infusion (ED50: 0.42 mg/kg/h) or bolus injection (1.2 mg/kg). Preliminary studies indicate no overt toxic effects of AE-3763 (300 mg/kg, i.v.) in mice.
Animal Research	D-Galactosamine shock is induced in C3H/HeN mice (6-7 w, 22-25 g). AE-3763 (10 or 100 mg/kg) is administrated intraperitoneally six times at 2 h interval. Control animals receive the vehicle (PBS) instead of AE-3763. The animal survival rate is observed up to 24 h after shock induction.

Chemical Properties

Molecular Weight	549.54
Formula	C₂₃H₃₄F₃N₅O₇
Cas No.	291778-77-3
Smiles	CC(C)[C@H](NC(=O)CN1CCN(CC(O)=O)C1=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)C(F)(F)F
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc