Shopping Cart
  • Remove All
  • TargetMol
    Your shopping cart is currently empty
TargetMol | Tags Metabolism
ANGPTL
(4)
ATP Citrate Lyase
(15)
Acetyl-CoA Carboxylase
(32)
Aconitase
(2)
Acyltransferase
(144)
Adenosine Deaminase
(16)
AhR
(31)
Amino Acids and Derivatives
(1026)
Aminopeptidase
(70)
Amylase
(41)
Angiotensin-converting Enzyme (ACE)
(172)
Apolipoprotein
(9)
CETP
(17)
CPT
(5)
Calcium Channel
(627)
Carbonic Anhydrase
(215)
Casein Kinase
(159)
Cytochromes P450
(491)
DHFR
(58)
Decarboxylase
(7)
Dehydrogenase
(468)
Drug Metabolite
(587)
Endogenous Metabolite
(3224)
Epoxide Hydrolase
(57)
FAAH
(72)
FABP
(15)
FXR
(78)
Factor VIII
(6)
Factor VIIa
(5)
Factor Xa
(92)
Fatty Acid Synthase
(70)
GSNOR
(3)
Glucokinase
(71)
Glucosidase
(219)
Glutathione Peroxidase
(73)
Glyoxalase
(17)
HIF/HIF Prolyl-Hydroxylase
(194)
HMG-CoA Reductase
(69)
HSP
(264)
Hexokinase
(9)
Hydrogenase
(2)
Hydroxylase
(45)
IDO
(94)
Indoleamine 2,3-Dioxygenase (IDO)
(98)
Isocitrate Dehydrogenase (IDH)
(46)
LDL
(26)
LDLR
(14)
Lipase
(37)
Lipid
(44)
Liposome
(442)
Lipoxygenase
(194)
Liver X Receptor
(51)
MAGL
(61)
MAO
(108)
Mitochondrial Metabolism
(212)
N-Acetylglucosaminyltransferase
(1)
NADPH
(62)
NAMPT
(44)
NEDD4-1
(3)
NEDD8
(8)
NUDIX hydrolase
(2)
Neprilysin
(31)
PAI-1
(38)
PDE
(528)
PGK1
(3)
PKM
(43)
PPAR
(386)
Phosphatase
(432)
Phospholipase
(201)
Phosphorylase
(21)
Photosystem (PS)
(5)
Procollagen C Proteinase
(1)
Prolyl Endopeptidase (PREP)
(33)
RAR/RXR
(12)
REV-ERB
(9)
ROR
(96)
Reactive Oxygen Species
(773)
Reductase
(121)
Retinoid Receptor
(109)
SGK
(24)
Serine/threonin kinase
(90)
Stearoyl-CoA Desaturase (SCD)
(29)
Taste receptor
(6)
Thioredoxin
(2)
Transaminase
(3)
Transferase
(222)
Transketolase
(9)
UGT
(17)
Vitamin
(89)
Xanthine Oxidase
(73)
glycosidase
(28)
hCE
(2)
stilbene oxidase
(1)
transporter
(87)

LDLR

LDLR (Low-Density Lipoprotein Receptor) is a cell surface receptor primarily responsible for cholesterol uptake and metabolism. Expressed in tissues including the liver, intestine, and arterial walls, LDLR regulates blood cholesterol levels by recognising and binding to low-density lipoprotein (LDL) particles, facilitating their internalisation and degradation. Dysfunction of LDLR is closely associated with hypercholesterolaemia and atherosclerosis. LDLR activity is regulated by multiple factors, including cholesterol levels and insulin, making it a valuable target for cardiovascular disease research.

Evolocumab
T99201256937-27-5
Evolocumab is an inhibitor of the humanized monoclonal antibody PCSK9. It binds to circulating PCSK9 protein, resulting in inhibition of PCSK9 binding to LDLR. It can be used in studies of hypercholesterolemia and atherosclerotic cardiovascular disease.
  • $397
In Stock
Size
QTY
TargetMol | Inhibitor Hot
Imanixil
T1556175689-93-9In house
Imanixil (HOE-402 free base) is an LDL receptor (LDLR) inducer, a hypolipidemic and hypocholesterolemic compound with antiatherogenic activity that inhibits the production of very low-density lipoproteins (VLDLs).Imanixil acts by stimulating the LDL receptor pathway.
  • $179
In Stock
Size
QTY
Coptisine
T5S00533486-66-6
1. Coptisine (Coptisin) treatment increases cell viability based on its reversal effect on the enhanced activity of Indoleamine 2, 3-dioxygenase . 2. Coptisine treats myocardial I/R likely through suppressing myocardial apoptosis and inflammation by inhibiting the Rho/ROCK pathway. 3. Coptisine is a potential anti-osteosarcoma drug candidate, via exerting a strong anti-osteosarcoma effect with very low toxicity . 4. Coptisine with a high dosage could inhibit cholesterol synthesis via suppressing the HMGCR expression and promoting the use and excretion of cholesterol via up-regulating LDLR and CYP7A1 expression. 5. Coptisine suppresses adhesion, migration and invasion of MDA-MB-231 breast cancer cells in vitro, the down-regulation of MMP-9 in combination with the increase of TIMP-1 possibly contributing to the anti-metastatic function for breast cancer.
  • $38
In Stock
Size
QTY
Compound T72025(SC)
T72025368434-98-4
PCSK9-IN-10, a potent and orally active inhibitor of Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9), exhibits a half-maximal inhibitory concentration (IC50) of 6.4 µM. By enhancing the expression of Low-Density Lipoprotein Receptor (LDLR) protein and reducing PCSK9 expression, PCSK9-IN-10 effectively decreases atherosclerosis progression. This compound holds promise for hyperlipidemia research applications.
  • $35
In Stock
Size
QTY
Pep 2-8 ammonium salt(1541011-97-5 free base)
TP1881L1
Pep 2-8 ammonium salt is Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor. Potent inhibitor of PCSK9 binding to LDL receptor (IC50 = 0.8 μM). Restores LDL uptake in HepG2 cells treated with PCSK9.
  • $137
In Stock
Size
QTY
PCSK9-IN-11
T67776
PCSK9-IN-11 (compound 5r) is a potent PCSK9 inhibitor with oral activity, exhibiting inhibitory activity on PCSK9 transcription in HepG2 cells (IC50 = 5.7 μM) and capable of increasing LDL receptor (LDLR) protein levels. PCSK9-IN-11 is applicable for atherosclerosis research.
  • $47
In Stock
Size
QTY
TargetMol | Inhibitor Sale
Propane-1,2,3-triyl tripalmitate
TWO2727555-44-2
Propane-1,2,3-triyl tripalmitate (Glycerol Tripalmitate) is a triacylglycerol found in dietary fats. In hamsters fed a diet enriched with it, Tripalmitin increases body weight, elevates plasma LDL levels, and reduces hepatic LDL receptor mRNA levels. It inhibits glucose-stimulated insulin secretion and decreases the viability of INS1 cells dose-dependently. Tripalmitin is used in cosmetic products for skin conditioning and as a thickening agent, and it forms lipid matrices of nanoparticles for drug delivery.
  • $38
In Stock
Size
QTY
Orticumab
T771231314241-10-5
Orticumab (MLDL1278A) is a recombinant human monoclonal antibody engineered to specifically bind to epitopes on oxidized low-density lipoprotein (oxLDL). it demonstrates therapeutic potential by modulating autoimmune responses against oxLDL, thereby improving atherosclerotic plaque pathology, and also shows significant promise for the treatment of autoimmune inflammatory conditions such as psoriasis.
  • $413
In Stock
Size
QTY
Kylo-0603
T2070232661053-09-2
KYLO-0603 is an orally active and selective THR-β agonist with an EC50 of 31.07 nM. It effectively reduces serum cholesterol and low-density lipoprotein cholesterol levels. By activating THR-β receptors, KYLO-0603 enhances the expression of THR-regulated genes like iodothyronine deiodinase 1 (Dio1), malic enzyme 1 (Me1), and thyroid hormone-responsive (Thrsp) gene, while it inhibits the expression of inflammatory and fibrosis-related genes, including low-density lipoprotein receptor (LDL-R) gene. This compound is applicable for the study of metabolic associated steatohepatitis (MASH) and liver fibrosis.
  • Inquiry Price
Size
QTY
S 12340
T70624144754-35-8
S 12340 is a potent inhibitor of the oxidative modification of low-density lipoprotein.
  • $1,520
6-8 weeks
Size
QTY
IETP2
TP31152314338-36-6
IETP2 targets low-density lipoprotein receptor-related protein 1 (LRP1) with a KD of 738 nM, making it useful for delivering drugs and imaging agents across the blood-labyrinth barrier (BLB).
  • Inquiry Price
Size
QTY
LY 295427
T33002152755-31-2
LY 295427 is a bioactive chemical.
  • $7,250
Backorder
Size
QTY
CAY10487
T35985778624-05-8
The early stage of atherosclerosis is characterized by the aggregation of foam cells, so called a fatty streak, in the inner arterial wall. CAY10487 inhibits formation of fatty streak lesions of the thoracic aorta in high cholesterol-fed rabbits without affecting plasma lipid profiles or significantly inhibiting ACAT-1 or ACAT-2 activity. The percent area occupied by the atherosclerotic lesion in rabbits supplemented with 0.05% CAY10487 in the diet was 16.1% compared to 53.5% in control rabbits. CAY10487 also exhibits antioxidant activity, inhibiting copper-mediated oxidation of low-density lipoprotein by about 75% at a concentration of 2 μM.
  • $105
35 days
Size
QTY
Milpocitide
T745772643306-81-2
Milpocitide, a (293-333)-peptide fragment of the human low-density lipoprotein receptor (LDLR), specifically corresponds to the EGF-like domain 1 [1].
  • Inquiry Price
Size
QTY