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LDLR (Low-Density Lipoprotein Receptor) is a cell surface receptor primarily responsible for cholesterol uptake and metabolism. Expressed in tissues including the liver, intestine, and arterial walls, LDLR regulates blood cholesterol levels by recognising and binding to low-density lipoprotein (LDL) particles, facilitating their internalisation and degradation. Dysfunction of LDLR is closely associated with hypercholesterolaemia and atherosclerosis. LDLR activity is regulated by multiple factors, including cholesterol levels and insulin, making it a valuable target for cardiovascular disease research.
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