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DC-174
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Catalog No. T211265 Copy Product Info
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DC-174 is an orally effective small molecule inhibitor of snake venom metalloproteinases (SVMPs) belonging to the hydroxamic acid class. As a candidate molecule optimized from the lead compound XL-784 through structure-activity relationship studies, it broadly inhibits the SVMP enzymatic activity of various snake venoms (e.g., saw-scaled viper, western diamondback rattlesnake, Malayan pit viper, etc.) with IC50 values below 10 nM by chelating the zinc ion in the SVMP active site via its hydroxamic acid group. It also neutralizes snake venom-induced procoagulant toxicity. Pharmacokinetic studies show that DC-174 reaches peak blood concentration approximately 30 minutes after oral administration but has a short half-life (approx. 1.41 hours). Optimized multi-dose regimens can prolong effective exposure time, demonstrating significant survival protection effects in severe snakebite mouse models, thus positioning it as a promising lead compound for developing oral emergency snakebite treatments.
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | Inquiry | Inquiry | |
| 50 mg | Inquiry | Inquiry | Inquiry |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | DC-174 is an orally effective small molecule inhibitor of snake venom metalloproteinases (SVMPs) belonging to the hydroxamic acid class. As a candidate molecule optimized from the lead compound XL-784 through structure-activity relationship studies, it broadly inhibits the SVMP enzymatic activity of various snake venoms (e.g., saw-scaled viper, western diamondback rattlesnake, Malayan pit viper, etc.) with IC50 values below 10 nM by chelating the zinc ion in the SVMP active site via its hydroxamic acid group. It also neutralizes snake venom-induced procoagulant toxicity. Pharmacokinetic studies show that DC-174 reaches peak blood concentration approximately 30 minutes after oral administration but has a short half-life (approx. 1.41 hours). Optimized multi-dose regimens can prolong effective exposure time, demonstrating significant survival protection effects in severe snakebite mouse models, thus positioning it as a promising lead compound for developing oral emergency snakebite treatments. |
| Molecular Weight | 419.47 |
| Formula | C15H21N3O7S2 |
| Smiles | O=S(N1C[C@H](C(NO)=O)N(S(=O)(C2=CC=C(OC)C=C2)=O)CC1)(C3CC3)=O |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Related Tags: DC-174 chemical structure | DC-174 formula | DC-174 molecular weight
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