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Rp-cAMPS sodium

Name: Rp-cAMPS sodium
Brand: TargetMol
SKU: T36679
Price: 299 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T36679Cas No. 142439-94-9

Rp-cAMPS sodium is a phosphorothioate analog of cAMP, a protein kinase A inhibitor and a membrane-permeable cAMP antagonist that inhibits cAMP-dependent protein kinases by blocking cAMP-induced conformational transitions, and can be used in the study of cardiovascular diseases.

Rp-cAMPS sodium

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Purity: 99.71%

Catalog No. T36679Cas No. 142439-94-9

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$299	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.71%

Appearance:Solid

Color:White

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COA LCMS

Product Introduction

Bioactivity

Description	Rp-cAMPS sodium is a phosphorothioate analog of cAMP, a protein kinase A inhibitor and a membrane-permeable cAMP antagonist that inhibits cAMP-dependent protein kinases by blocking cAMP-induced conformational transitions, and can be used in the study of cardiovascular diseases.
Targets&IC50	PKA I:6.05 µM (Ki), PKA II:9.75 µM (Ki)
In vitro	METHODS: To measure the inhibitory effect of Rp-cAMPS sodium on purified type II cAMP-dependent protein kinase, different concentrations of Rp-cAMPS sodium were added, and their impact on cAMP-induced phosphotransferase activity was observed. RESULTS: Rp-cAMPS sodium binds to cAMP but does not cause enzyme dissociation, thereby inhibiting the activity of the phosphotransferase[2].
In vivo	METHODS: To investigate the effect of Rp-cAMPS sodium on synaptic transmission in a rat arthritis model, particularly its modulation of PB-CeLC and BLA-CelC synapses, EPSCs were evoked by stimulating the PB-CeLC and BLA-CelC synapses, and the changes before and after treatment were compared. RESULTS: Treatment with Rp-cAMPS sodium (10 μM, 15 minutes) significantly reduced the evoked single-synaptic EPSCs at the PB-CeLC and BLA-CelC synapses [2].

Chemical Properties

Molecular Weight	367.25
Formula	C₁₀H₁₁N₅NaO₅PS
Cas No.	142439-94-9
Smiles	O[C@H]1[C@@H](O[C@@]2([H])[C@@]1([H])OP([S-])(OC2)=O)N3C4=NC=NC(N)=C4N=C3.[Na+]

Storage & Solubility Information

Storage

store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 80 mg/mL (217.84 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	2.7229 mL	13.6147 mL	27.2294 mL	136.1470 mL
5 mM	0.5446 mL	2.7229 mL	5.4459 mL	27.2294 mL
10 mM	0.2723 mL	1.3615 mL	2.7229 mL	13.6147 mL
20 mM	0.1361 mL	0.6807 mL	1.3615 mL	6.8074 mL
50 mM	0.0545 mL	0.2723 mL	0.5446 mL	2.7229 mL
100 mM	0.0272 mL	0.1361 mL	0.2723 mL	1.3615 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc