d2

Dopamine D2 Receptor Antagonist-1 functions as a negative allosteric modulator (NAM) of the dopamine D2 receptor (D2R), demonstrating sub-millimolar affinity.

Ergocalciferol (Vitamin D2 (Calciferol)) is a derivative of ergosterol formed by ultraviolet rays breaking of the C9-C10 bond with a strong inhibitory effect against bladder tumor promotion by sodium saccharin, and it induces cell differentiation in leukemia cells. Vitamin D2 is an inhibitor of DNA Polymerase.

Resolvin D2 (RvD2) is a potent TRPV1 inhibitor and pro-absorptive mediator with anti-inflammatory, anti-infective and pro-absorptive effects for the study of immune disorders and cancer.

Prostaglandin D2 (PGD2), a major prostaglandin produced actively in the brains of various mammals, is a potent endogenous sleep-promoting substance.

24, 25-Dihydroxy VD2 (24,25-Dihydroxy vitamin D2) is a metabolite of vitamin D2, which is the isomer of vitamin D present in the body as 25-hydroxyvitamin D. PF-04957325 is used in the study of autoimmune encephalomyelitis.

Prostaglandin D2 (PGD2) is the major eicosanoid product of mast cells and is produced in large quantities by hematopoietic PGD synthase during allergic and asthmatic anaphylaxis. It causes vasodilation, flushing, hypotension, and is an inhibitor of platelet aggregation. Prostaglandin D2 methyl ester (PGD2 methyl ester) is a more lipid-soluble, cell-permeable prodrug form of PGD2. It binds to the human and mouse PGD2 receptors (DP1 and CRTH2/DP2) with 5-10 fold lower affinity than PGD2.

Resolvin D2 (RvD2) is a lipid mediator biosynthesized by the sequential oxygenation of docosahexaenoic acid by 15- and 5-lipoxygenase. It evokes diverse anti-inflammatory effects which may mediate the resolution of inflammation. RvD2 methyl ester is a methyl ester version of the free acid which may act as a lipophilic prodrug form that will alter its distribution and pharmacokinetic properties. The methyl ester moiety is susceptible to cleavage by intracellular esterases, leaving the free acid.

15(R)-15-methyl Prostaglandin D2 (15(R)15methyl PGD2) is a synthetic analogue of PGD2 and a selective and potent CRTH2/DP2 receptor agonist that modulates eosinophil CD11b expression, actin polymerisation and chemotaxis.

Prostaglandin D2 ethanolamide (PGD2-EA) is a bioactive lipid produced by the sequential metabolism of anandamide (arachidonoyl ethanolamide) by cyclooxygenase (COX) enzymes, in particular by COX-2, and PGD synthase. The biosynthesis of PGD2-EA from anandamide can also be increased when anandamide metabolism is diminished by deletion of fatty acid amide hydrolase. PGD2-EA is inactive against recombinant prostanoid receptors, including the D prostanoid receptor. It increases the frequency of miniature inhibitory postsynaptic currents in primary cultured hippocampal neurons, an effect which is the opposite of that induced by anandamide.. PGD2-EA also induces apoptosis in colorectal carcinoma cell lines.

Dopamine D2 receptor agonist-2 (Dopamine D2 Receptor) is a ligand targeting the dopamine D2 receptor.

17β-Estradiol-2,4-D2 (Standard) is a reference material suitable for analytical purposes, including quantitative analysis, quality control, and biochemical experiments.

Metronidazole-hydroxy-D2 (Standard) is the standard substance of Metronidazole-hydroxy-D2, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Metronidazole-hydroxy-D2 is a deuterated compound of Metronidazole-hydroxy. Metronidazole-hydroxy (T40573) has a CAS number of 4812-40-2.

Z,Z-Dienestrol-D2 (Standard) is the standard substance of Z,Z-Dienestrol-D2, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Z,Z-Dienestrol-D2 is a deuterated compound of Z,Z-Dienestrol. Z,Z-Dienestrol (T211675) has a CAS number of 35495-11-5.

17α-Hydroxypregnenolone-[13C2,D2] (Standard) is a reference standard of 17α-Hydroxypregnenolone-[13C2,D2] intended for quantitative analysis, quality control, and related biochemical research applications.

Pyridoxine-[D2] (Standard) is a reference standard of Pyridoxine-[D2] intended for quantitative analysis, quality control, and related biochemical research applications.

Pyridoxine-D2 Hcl (Standard) is a reference standard of Pyridoxine-D2 Hcl intended for quantitative analysis, quality control, and related biochemical research applications. Pyridoxine-d2 HCl is a deuterated compound of Pyridoxine HCl. Pyridoxine HCl has a CAS number of 58-56-0. Pyridoxine hydrochloride is the 4-methanol form of vitaminB6 which is converted to pyridoxal phosphate which is a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid.

Biotin-D2 (Standard) is a reference standard of Biotin-D2 intended for quantitative analysis, quality control, and related biochemical research applications. Biotin-d2 is a deuterated compound of Biotin. Biotin has a CAS number of 58-85-5. Biotin is a water-soluble B-vitamin and is necessary for cell growth, the production of fatty acids, and the metabolism of fats and amino acids.

Cortisol-1,2-D2 (Standard) is a reference standard of Cortisol-1,2-D2 intended for quantitative analysis, quality control, and related biochemical research applications. Cortisol-1,2-d2 is a deuterated compound of Cortisol. Cortisol has a CAS number of 50-23-7. Hydrocortisone, a glucocorticoid receptor agonist, promotes protein catabolism, gluconeogenesis, capillary wall stability, renal excretion of calcium, and suppresses immune and inflammatory responses. Therapeutic Hydrocortisone is a synthetic or semisynthetic analog of natural hydrocortisone hormone produced by the adrenal glands with primary glucocorticoid and minor mineralocorticoid effects.

16α-Hydroxy-17β-Estradiol-2,4-D2 (Standard) is a reference standard of 16α-Hydroxy-17β-Estradiol-2,4-D2 intended for quantitative analysis, quality control, and related biochemical research applications. 16α-Hydroxy-17β-estradiol-2,4-d2 is a deuterated compound of Estriol. Estriol has a CAS number of 50-27-1. Estriol is a hydroxylated metabolite of ESTRADIOL or ESTRONE that has a hydroxyl group at C3, 16-alpha, and 17-beta position. Estriol is a major urinary estrogen. During PREGNANCY, a large amount of estriol is produced by the PLACENTA.

Estrone-D2 (Standard) is a reference standard of Estrone-D2 intended for quantitative analysis, quality control, and related biochemical research applications. Estrone-d2 is a deuterated compound of Estrone. Estrone has a CAS number of 53-16-7. Estrone is an aromatized C18 steroid with a 3-hydroxyl group and a 17-ketone, a major mammalian estrogen. It is converted from ANDROSTENEDIONE directly, or from TESTOSTERONE via ESTRADIOL. In humans, it is produced primarily by the cyclic ovaries, PLACENTA, and the ADIPOSE TISSUE of men and postmenopausal women.

17Alpha-Estradiol-2,4-D2 (Standard) is a reference standard of 17Alpha-Estradiol-2,4-D2 intended for quantitative analysis, quality control, and related biochemical research applications. 17alpha-Estradiol-2,4-d2 is a deuterated compound of 17alpha-Estradiol. 17alpha-Estradiol has a CAS number of 57-91-0. Endogenous estrogen receptor ligand (Ki values are 0.2 and 1.2 nM for ERα and ERβ receptors respectively).

Methylprednisolone-D2 (Standard) is a reference standard of Methylprednisolone-D2 intended for quantitative analysis, quality control, and related biochemical research applications. Methylprednisolone-d2 is a deuterated compound of Methylprednisolone. Methylprednisolone has a CAS number of 83-43-2. Methylprednisolone is a PREDNISOLONE derivative with similar anti-inflammatory action.

(4-Hydroxy-3-Methoxyphenyl)Acetic-2,2-D2 Acid (Standard) is a reference standard of (4-Hydroxy-3-Methoxyphenyl)Acetic-2,2-D2 Acid intended for quantitative analysis, quality control, and related biochemical research applications. (4-Hydroxy-3-methoxyphenyl)acetic-2,2-d2 Acid is a deuterated compound of (4-Hydroxy-3-methoxyphenyl)acetic Acid. (4-Hydroxy-3-methoxyphenyl)acetic Acid has a CAS number of 306-08-1. Homovanillic acid is a dopamine metabolite found to be associated with aromatic L-amino acid decarboxylase deficiency, celiac disease, growth hormone deficiency, and sepiapterin reductase deficiency.

Indole-3-Acetic-D2 Acid (Standard) is a reference standard of Indole-3-Acetic-D2 Acid intended for quantitative analysis, quality control, and related biochemical research applications. Indole-3-Acetic-d2 Acid is a deuterated compound of Indole-3-Acetic Acid. Indole-3-Acetic Acid has a CAS number of 87-51-4. 3-Indoleacetic acid (IAA) is the most common plant hormone of the auxin class and it regulates various aspects of plant growth and development.