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tetranor-PGDM

Catalog No. T38306 CAS 70803-91-7

Prostaglandin D2 is synthesized by hematopoietic-type PGD-synthase (H-PGDS) in mast cells and is released in large quantities during allergic and asthmatic anaphylaxis. PGD2 is also produced in the brain by lipocalin-PGD-synthase also known as β-trace. In the brain, PGD2 produces normal physiological sleep and lowering of body temperature. Further pharmacological actions include inhibition of platelet aggregation and relaxation of vascular smooth muscle. tetranor-PGDM is a major metabolite of PGD2 that is detectable in human and mouse urine. The levels of tetranor-PGDM and 2,3-dinor-11β-PGF2α , a related PGD2 metabolite, in human urine were found to be 1.5 ± 0.3 and 0.6 ± ng/mg creatinine, respectively. tetranor-PGDM was detected in murine urine at a level of 8.1 ± 1.3 ng/mg creatinine.

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tetranor-PGDM, CAS 70803-91-7

Pack Size	Availability	Price/USD
25 μg	35 days	$ 396.00
50 μg	35 days	$ 765.00
100 μg	35 days	$ 1,440.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Molecular Weight	328.361
Formula	C16H24O7
CAS No.	70803-91-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMF: 50 mg/mL

DMSO: 50 mg/mL

Ethanol: 50 mg/mL

PBS (pH 7.2): 1 mg/mL

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Keywords

tetranor-PGDM 70803-91-7 tetranorPGDM tetranor PGDM inhibitor inhibit

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