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tetranor-PGDM

Name: tetranor-PGDM
Brand: TargetMol
SKU: T38306
Rating: 4.5 (1 reviews)

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Catalog No. T38306Cas No. 70803-91-7

Prostaglandin D2 is synthesized by hematopoietic-type PGD-synthase (H-PGDS) in mast cells and is released in large quantities during allergic and asthmatic anaphylaxis. PGD2 is also produced in the brain by lipocalin-PGD-synthase also known as β-trace. In the brain, PGD2 produces normal physiological sleep and lowering of body temperature. Further pharmacological actions include inhibition of platelet aggregation and relaxation of vascular smooth muscle. tetranor-PGDM is a major metabolite of PGD2 that is detectable in human and mouse urine. The levels of tetranor-PGDM and 2,3-dinor-11β-PGF2α , a related PGD2 metabolite, in human urine were found to be 1.5 ± 0.3 and 0.6 ± ng/mg creatinine, respectively. tetranor-PGDM was detected in murine urine at a level of 8.1 ± 1.3 ng/mg creatinine.

tetranor-PGDM

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Catalog No. T38306Cas No. 70803-91-7

Pack Size	Price	USA Warehouse	Global Warehouse
25 μg	$573	35 days	35 days
50 μg	$1,090	35 days	35 days
100 μg	$1,980	35 days	35 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description

Chemical Properties

Molecular Weight	328.361
Formula	C₁₆H₂₄O₇
Cas No.	70803-91-7
Smiles	O[C@H]1CC(=O)[C@H](CCC(=O)CCCCC(O)=O)[C@H]1CCC(O)=O

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMF: 50 mg/mL (152.27 mM), Sonication is recommended.

DMSO: 50 mg/mL (152.27 mM), Sonication is recommended.

Ethanol: 50 mg/mL (152.27 mM), Sonication is recommended.

PBS (pH 7.2): 1 mg/mL (3.05 mM), Sonication is recommended.

Solution Preparation Table

PBS (pH 7.2)/DMF/DMSO/Ethanol

	1mg	5mg	10mg	50mg
1 mM	3.0454 mL	15.2271 mL	30.4543 mL	152.2714 mL

DMF/DMSO/Ethanol

	1mg	5mg	10mg	50mg
5 mM	0.6091 mL	3.0454 mL	6.0909 mL	30.4543 mL
10 mM	0.3045 mL	1.5227 mL	3.0454 mL	15.2271 mL
20 mM	0.1523 mL	0.7614 mL	1.5227 mL	7.6136 mL
50 mM	0.0609 mL	0.3045 mL	0.6091 mL	3.0454 mL
100 mM	0.0305 mL	0.1523 mL	0.3045 mL	1.5227 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc