1,4-naphthoquinone

1,4-Naphthoquinone (P-Naphthoquinone) was used as a potential inhibitor of monoamine oxidase and DNA topoisomerase activities[2]. It was also used to inhibit the acetyltransferase activity[1].

2-Carbamoyl-3-hydroxy-1,4-naphthoquinone is a natural product for research related to life sciences. The catalog number is TN5790 and the CAS number is 103646-20-4.

1,4-Naphthoquinone-NH-C2-NH-Trolox is a compound that combines Trolox and vitamin K, known for its neuroprotective properties and ability to penetrate the blood-brain barrier. It effectively inhibits processes such as oxytosis (oxidative cell death), ferroptosis, ATP depletion, and reactive oxygen species (ROS) production. Additionally, it selectively suppresses the expression of M1 markers and can be utilized in research on neurological disorders like Alzheimer's disease (AD).

2-Amino-3-carboxy-1,4-naphthoquinone is an electron transfer mediator that can alter glucose metabolism in homofermentative lactic acid bacteria. It also serves as a novel growth stimulator for bifidobacteria, influencing their end-product profile through the mediated oxidation of NAD(P)H.

6-Methyl-1,4-naphthoquinone is a reagent used in biochemical reactions.

Lawsone (Hennotannic acid) (2-hydroxy-1,4-naphthoquinone), also known as hennotannic acid, is a red-orange dye present in the leaves of the henna plant (Lawsonia inermis) as well as in the flower of water hyacinth (Eichhornia crassipes).

Lawsone methyl ether (2-Methoxy-1,4-naphthoquinone) induces apoptosis in A549 cells independently of cell cycle arrest, mediated by JNK and p38 MAPK signaling pathways. These pathways are activated due to oxidative DNA damage from increased ROS generation in MNQ-treated A549 cells.

Juglone (Regianin) is a natural naphthoquinone found in the black walnut (J. nigra) and other plants in the Juglandaceae family. Juglone also irreversibly inhibits peptidyl-prolyl cis/trans isomerases of the parvulin family, including human Pin1, yeast Ess1/Ptf1, and E. coli parvulin (Ki = 55.9 nM). Juglone also blocks transcription by RNA polymerases I, II, and III (IC50s = 2-7 μM) and attenuates kidney fibrosis in rats treated with unilateral ureteral obstruction, both through Pin1-independent mechanisms.

2-Chloronaphthoquinone (2-Chloro-1,4-naphthoquinone) is a substituted naphthoquinone which is used as an insecticide and acaricide.

Antimalarial agent 14 (NSC-102533) is a bioactive chemical.

6-Ethoxyethyl-5-hydroxy-2,7-dimethoxy-1,4-naphthoquinone is a naphthoquinone compound known to cause withering of larch branches and inhibit the germination and growth of lettuce seeds. At a concentration of 100 ppm, it completely inhibits the growth of hypocotyls and roots, and at 50 ppm, it suppresses over 95%.

MEK Inhibitor II (2-Chloro-3-(N-succinimidyl)-1,4-naphthoquinone) is a selective MEK1 inhibitor (IC50=0.38 μM) that inhibits tubulin polymerization in Trypanosoma cruzi (IC50=6 μM) and exhibits inhibitory activity against trypanosomes (IC50=2.77 μM).

AK-135 is a derivative of 1,4-naphthoquinone (Menadione). AK-135 has been shown to restore the electron flow in defective respiratory chain (hypoxia or rotenone) systems more effectively than Menadione.

DMNQ is a 1,4-naphthoquinone that acts as a redox-cycling agent, typically increasing intracellular superoxide and hydrogen peroxide formation.DMNQ increases ROS generation

Naphthazarin (5,8-Dihydroxy-1,4-naphthoquinone) is effective by various cellular mechanisms including oxidative stress, activation of mitochondrial apoptosis-inducing factor (AIF), depolymerization of microtubules, interference with lysosomal function and p53-dependent p21 activation. It triggers apoptosis and has anti-tumor effects

Vitamin K3-D3 (Standard) is a reference standard of Vitamin K3-D3 intended for quantitative analysis, quality control, and related biochemical research applications. Vitamin K3-d3 is a deuterated compound of Vitamin K3. Vitamin K3 has a CAS number of 58-27-5. Menadione is a synthetic naphthoquinone without the isoprenoid side chain and biological activity, but can be converted to active vitamin K2, menaquinone, after alkylation in vivo.

Vitamin K3-D8 (Standard) is a reference standard of Vitamin K3-D8 intended for quantitative analysis, quality control, and related biochemical research applications. Vitamin K3-d8 is a deuterated derivative of Vitamin K3, and Vitamin K3-d8, like Menadione (Vitamin K3), is a synthetic naphthoquinone lacking the isoprenoid side chain and intrinsic biological activity; however, Vitamin K3-d8 can be enzymatically converted into active Vitamin K2 (menaquinone) following in vivo alkylation, supporting research into vitamin K metabolism, biochemical labeling studies, and isotope-tracer investigations in metabolic and nutritional sciences.

Chimaphilin is a natural product for research related to life sciences. The catalog number is TN5795 and the CAS number is 482-70-2.