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Cat No. | Product Name | Synonyms | Targets |
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T1834 | CX-6258 | CX 6258 | Pim |
CX-6258 is an orally valid Pim 1/2/3 kinase(IC50=5 nM/25 nM/16 nM) inhibitor. It has good biological activity and kinase specificity. | |||
T3058 | (Z)-SMI-4a | TCS PIM-1 4a,SMI-4a | Pim |
(Z)-SMI-4a (TCS PIM-1 4a) is a selective ATP-competitive Pim-1 kinase inhibitor with an IC50 of 21 nM. | |||
T6148 | CX-6258 hydrochloride | CX-6258 HCl,Pim-Kinase Inhibitor X | Pim |
CX-6258 hydrochloride (Pim-Kinase Inhibitor X) is an effective, orally efficacious Pim1/2/3 kinase inhibitor (IC50: 5/25/16 nM). | |||
T4215 | TCS-PIM-1-4a | SMI-4a | Apoptosis , Pim |
TCS-PIM-1-4a (SMI-4a), a Pim inhibitor, blocks mTORC1 activity through activation of AMPK and kills a wide range of both myeloid and lymphoid cell lines (IC50=0.8-40 μM). | |||
T9229 | Pim-1/2 kinase inhibitor 1 | Pim | |
Pim-1/2 Kinase Inhibitor 1, an orally active inhibitor, impedes the action of Pim kinases by preventing their ability to phosphorylate peptides. It particularly inhibits the phosphorylation of 4E-BP1 and p27 Kip1 by Pim ... | |||
T1742 | 4E1rcat | PERK , Autophagy | |
4E1RCat is a dual inhibitor of eIF4E:eIF4 g and eIF4E:4E-BP1 interaction. And it inhibits the binding of eIF4 g to eIF4E with IC50 of 3.2 μM. | |||
T39958 | (32-Carbonyl)-RMC-5552 | ||
(32-Carbonyl)-RMC-5552 is a highly effective mTOR inhibitor, exhibiting inhibitory effects on both mTORC1 and mTORC2 substrate phosphorylation. Specifically, it significantly suppresses the phosphorylation of p-P70S6K-(T... | |||
T39776 | RMC-4529 | ||
RMC-4529 is a chemical compound that demonstrates potent inhibition, with an IC50 value of 1.0 nM, against p-4E-BP1-(T37/46) in mTOR kinase cellular assays. |
Cat No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-01769 | 4EBP1 Protein, Human, Recombinant (His) | Human | E. coli |
The translational suppressor eIF4E binding protein-1, 4E-BP1 functions as a key regulator in cellular growth, differentiation, apoptosis and survival. The Eif4ebp1 gene, encoding 4E-BP1, is a direct target of a transcrip... |