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Natural Products Natural ProductsTraditional Chinese Medicine Compound
The efficacy of traditional Chinese medicine has been validated through millennia of clinical practice, playing a vital role in disease prevention and human health maintenance. However, due to complex mechanisms of action and inconsistent quality standards, its application within modern medical systems still faces certain challenges. With the accelerated modernization of traditional Chinese medicine, research on its bioactive compounds has become a key direction for elucidating the mechanisms and advancing innovative drug development. Compared to synthetic compounds, these bioactive monoers exhibit greater structural diversity and biological activity, facilitating cellular uptake and target binding. In the exploration of drug development targeting challenging targets, natural products also hold advantages.
Forskolin
Cited
FSK, Colforsin, Coleonol
T293966575-29-9
Forskolin (Coleonol) is a natural product, an adenylate cyclase activator (EC50=0.5 μM). Forskolin increases cAMP levels, activates PXR and FXR, and induces autophagy. Forskolin produces positive inotropic effects in the heart, and has platelet anticoagulant and antihypertensive effects.
- $36
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CitedNimbolide Cited
T1632425990-37-8
Nimbolide suppresses CDK4/CDK6 kinase activity. Nimbolide inhibits the NF-κB, Wnt, PI3K-Akt, MAPK, and JAK-STAT signaling pathways. Nimbolide causes apoptosis through the inactivation of NF-κB. Nimbolide is a triterpene derived from the leaves and flowers
- $65
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CitedPaclitaxel Cited
Taxol, NSC 125973
T096833069-62-4
Paclitaxel (Taxol) is a natural product and a microtubule polymer stabilizer. Paclitaxel has anti-tumor activity and causes cell death by inducing mitotic arrest, apoptosis, and cell autophagy.
- $34
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Cited5-O-Caffeoylshikimic acid Cited
TN129573263-62-4
5-O-Caffeoylshikimic acid shows anti-oxidative activity; it also shows anti-inflammatory activity, the underlying mechanism was associated with downregulation of nuclear factor-κB.
- $98
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CitedDocosahexaenoic Acid Cited
DHA, Cervonic acid
T53696217-54-5
Docosahexaenoic Acid (DHA) is an essential omega-3 fatty acid prevalent in the brain and retina.
- $34
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CitedWighteone
Erythrinin B, 6-Isopentenylgenistein
TN525451225-30-0
Wighteone (Erythrinin B) is a small molecule compound derived from Genista ephedroides with potential antifungal and anticancer activity against EGFR L858R/T790M mutant non-small cell lung cancer.
- $73
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Punicalagin Cited
T392165995-63-3
Punicalagin is a major ellagitannin found in pomegranates that is reported to produce antioxidant, anti-inflammatory, and anticancer effects. It has been shown to prevent high-fat diet-induced obesity-associated accumulation of cardiac triglyceride and ch
- $38
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CitedL-Lactic acid
L-(+)-Lactic acid, 2-HYDROXYPROPIONIC ACID, (S)-2-Hydroxypropanoic acid
T484579-33-4
L-Lactic acid ((S)-2-Hydroxypropanoic acid) is a natural product produced by the anaerobic glycolysis of pyruvic acid. L-Lactic acid is a sensitive indicator of tissue hypoxia and can be used as a hemodynamic indicator in critically ill patients.
- $41
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(-)-Catechin
(-)-Cianidanol, (-)-Catechuic acid
T1359718829-70-4
(-)-Catechin ((-)-Cianidanol), an isomer of catechin, inhibits cyclooxygenase-1 (COX-1) with an IC50 of 1.4 μM.
- $40
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Sakuranetin
TN11262957-21-3
Sakuranetin, a flavanone phytoalexin from ultraviolet-irradiated rice leaves, it has antifungal, antimutagenic, anti-inflammatory and antioxidant effects
- $40
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Brefeldin A Cited
Decumbin, Cyanein, BFA, Ascotoxin
T606220350-15-6
Brefeldin A (Cyanein) belongs to the class of macrolide antibiotics and is an ATPase inhibitor (IC50=0.2 μM). Brefeldin A can induce tumor cell differentiation and apoptosis, and also possesses autophagy inhibitory activity.
- $34
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CitedGinkgetin Cited
T4S2126481-46-9
1. Ginkgetin has anti-influenza virus and anti-fungal activities. 2. Ginkgetin has anti-inflammatory activity, can down-regulates COX-2 induction in vivo against skin inflammatory responses. 3. Ginkgetin is a good STAT3 inhibitor and may be a useful lead
- $40
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CitedATP Cited
Triphosphoric acid adenosine ester, Triphosphaden, Atipi, Ara-ATP, Adenosine triphosphate
T2008956-65-5
ATP (Adenosine triphosphate) provides cellular energy, participates in overall energy balance, and maintains intracellular homeostasis. ATP can act as an extracellular signaling molecule through interactions with specific purinergic receptors to mediate a variety of processes including neurotransmission, inflammation, apoptosis, and bone remodeling.
- $34
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CitedQuercetin Cited
Sophoretin
T2174117-39-5
Quercetin, a flavonoid natural product, is a SIRT1 activator. It is also a PI3K inhibitor, inhibiting PI3Kγ, PI3Kδ, and PI3Kβ with IC50 values of 2.4, 3.0, and 5.4 μM, respectively. Recognized as a heat shock protein inhibitor, Quercetin can significantly reduce exosome release in TII models by downregulating Hsp70 or Hsp90.
- $42
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CitedXanthohumol
T33426754-58-1
Xanthohumol, also known as 2', 4, 4'-trihydroxy-6'-methoxy-3'-prenylchalcone or desmethylxanthohumol, is a member of the class of compounds known as 3-prenylated chalcones. It inhibits COX-1 and COX-2 activity and shows chemopreventive effects.
- $61
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Brassinolide
Brassin lactone
T315172962-43-7
Brassinolide (Brassin lactone) is a plant hormone isolated from rapeseed (Brassica napus) promoting stem elongation and cell division.
- $39
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Arachidonic acid Cited
Vevodar, Immunocytophyte, Immunocytophyt, arachidonate
T4129506-32-1
Arachidonic acid (Immunocytophyt) is a polyunsaturated omega-6 essential fatty acid that serves as a major component of biological membranes and animal phospholipids. It is synthesized from dietary linoleic acid and acts as a precursor to lipid mediators such as prostaglandins, thromboxanes, and leukotrienes. Arachidonic acid can improve cognitive responses and cardiovascular function and is commonly used to induce paw edema models.
- $39
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CitedTimosaponin A1
T2S229568422-00-4
Timosaponin A1, a coprostane-type steroidal saponin, is found in Rhizoma Anemarrhenae.
- $54
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Robinin Cited
NSC 9222
T2S0265301-19-9
Flavone glycoside from Robinia with antibacterial and diuretic properties; derived from kaempferol.The ability of robinin to reverse the multidrug resistance of the human colon cancer cell line Colo 320 expreβing MDR1/LRP was explored by monitoring their uptake of Rhodamine 123, but was shown to have minimal effect. Robinin (NSC-9222) was detected in lysates of the human breast cancer cell line MCF-7 using liquid chromatography-tandem maβ spectrometry.
- $68
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CitedProcyanidin B1
TQ020520315-25-7
Procyanidin B1, isolated from commonly eaten fruits, binds to the TLR4/MD-2 complex and has anti-inflammatory activity.
- $47
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Resveratrol Cited
trans-Resveratrol, SRT 501
T1558501-36-0
Resveratrol (SRT 501) is a polyphenolic natural product, a plant antitoxin with antioxidant and chemopreventive activities. Resveratrol has a wide range of targets including COX, SIRT, LOC, etc. Resveratrol induces autophagy and apoptosis.
- $36
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CitedErianin Cited
T386495041-90-0
Erianin is a nature product extracted from Dendrobium chrysotoxum, has notable antitumour activity , can cause extensive tumour necrosis, growth delay. Erianin has antiangiogenic action by inhibiting endothelial metabolism in a JNK/SAPK-dependent manner a
- $41
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CitedGanoderic acid A Cited
T6S114181907-62-2
1. Ganoderic acid A exhibits antitumor activity, mediated through its inhibitory effect on nuclear transcription factor-kappaB and activator protein-1. 2. Ganoderic acid A can induce proliferation inhibition, apoptosis and suppression of invasion in human
- $39
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CitedMulberrin
Kuwanon C
TQ016162949-79-5
Mulberrin (Kuwanon C) is an inhibitor of OATP2B1-mediated estrone-3-sulfate (E3S) uptake (IC50: 1.8 ±1.5 μM).
- $55
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