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Adenosylcobalamin

Name: Adenosylcobalamin
Brand: TargetMol
SKU: T14128
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T14128Cas No. 13870-90-1

Alias Coenzyme B12, Cobamamide, AdoCbl

Adenosylcobalamin (AdoCbl) is a biologically active form of vitamin B12 .It is a cofactor for methylmalonyl CoA mutase. It belongs to the corrinoid group of compounds, which contain a corrin macrocycle, and is produced only by certain bacteria and archaea. It is a cofactor for various enzymes including mutases, eliminases, aminomutases, and a reductase.

Adenosylcobalamin

🥰Excellent

Purity: 99.46%

Catalog No. T14128Alias Coenzyme B12, Cobamamide, AdoCblCas No. 13870-90-1

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$30	In Stock	In Stock
25 mg	$41	In Stock	In Stock
50 mg	$55	In Stock	In Stock
100 mg	$74	In Stock	In Stock
200 mg	$106	In Stock	In Stock
500 mg	$173	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$45	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:99.46%

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COA LCMS

Product Introduction

Bioactivity

Description	Adenosylcobalamin (AdoCbl) is a biologically active form of vitamin B12 .It is a cofactor for methylmalonyl CoA mutase. It belongs to the corrinoid group of compounds, which contain a corrin macrocycle, and is produced only by certain bacteria and archaea. It is a cofactor for various enzymes including mutases, eliminases, aminomutases, and a reductase.
In vitro	Adenosylcobalamin acts as the cofactor for a group of enzymes that catalyze unusual rearrangement or elimination reactions[1].
Synonyms	Coenzyme B12, Cobamamide, AdoCbl

Chemical Properties

Molecular Weight	1579.58
Formula	C₇₂H₁₀₀CoN₁₈O₁₇P
Cas No.	13870-90-1
Smiles	Nc1ncnc2n(cnc12)[C@H]1O[C@H](C[Co++])[C@H](O)[C@@H]1O.[H][C@]12[N-]\C(=C(C)/C3=N/C(=C\C4=N\C(=C(C)/C5=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]5CCC(N)=O)\[C@@](C)(CC(N)=O)[C@@H]4CCC(N)=O)/C(C)(C)[C@@H]3CCC(N)=O)[C@](C)(CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@@H]1[C@@H](CO)O[C@@H]([C@@H]1O)n1cnc3cc(C)c(C)cc13)[C@H]2CC(N)=O
Relative Density.	no data available

Storage & Solubility Information

Storage

keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 4 mg/mL (2.53 mM), Sonication is recommended.

DMSO: 41 mg/mL (25.96 mM)

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (1.27 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	0.6331 mL	3.1654 mL	6.3308 mL	31.6540 mL

DMSO

	1mg	5mg	10mg	50mg
5 mM	0.1266 mL	0.6331 mL	1.2662 mL	6.3308 mL
10 mM	0.0633 mL	0.3165 mL	0.6331 mL	3.1654 mL
20 mM	0.0317 mL	0.1583 mL	0.3165 mL	1.5827 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc