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25S-Inokosterone

Name: 25S-Inokosterone
Brand: TargetMol
SKU: TN1228
Price: 95 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TN1228 Copy Product Info

Purity: 99.99%

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25S-Inokosterone is a plant ecdysosteroid isolated from the roots of Achyranthes bidentata. 25S-Inokosterone shows potential for use in studies of LPS-induced acute kidney injury.

Cas No. 19595-18-7

Pack Size	Price	USA Stock	Global Stock
1 mg	$95	-	In Stock
5 mg	$228	-	In Stock
10 mg	$337	-	In Stock
25 mg	$569	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.99%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Bioactivity

Description

25S-Inokosterone is a plant ecdysosteroid isolated from the roots of Achyranthes bidentata. 25S-Inokosterone shows potential for use in studies of LPS-induced acute kidney injury.

In vitro

Methods: Rat renal tubular epithelial NRK52e cells were divided into a control group, an LPS model group (1 μg/mL), and a 25S-Inokosterone group (10 μM + LPS). The cells were treated for 24 hours, and cell viability was assessed using the CCK-8 assay, while apoptosis rates were measured by flow cytometry.
Results: 25S-Inokosterone significantly reversed the LPS-induced decrease in cell viability and significantly reduced LPS-induced apoptosis. [1]
Methods: RBL-2H3 cells were pretreated with 200 μg/mL 25S-Inokosterone for 1 h, then stimulated with PMA (1 μg/mL) + A23187 (1 μM) for 24 h; TNF-α levels in the supernatant were measured by ELISA.
Results: 25S-Inokosterone significantly inhibited TNF-α secretion, with an inhibition rate of approximately 80%. [2]

Chemical Properties

Molecular Weight	480.64
Formula	C₂₇H₄₄O₇
Cas No.	19595-18-7
Smiles	O[C@]12C=3[C@@]([C@]4(C)[C@](C(=O)C3)(C[C@@H](O)[C@@H](O)C4)[H])(CC[C@]1(C)[C@@]([C@@]([C@@H](CC[C@@H](CO)C)O)(C)O)(CC2)[H])[H]
Relative Density.	no data available

Storage & Solubility Information

Storage

Keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40 mg/mL (83.22 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0806 mL	10.4028 mL	20.8056 mL	104.0280 mL
5 mM	0.4161 mL	2.0806 mL	4.1611 mL	20.8056 mL
10 mM	0.2081 mL	1.0403 mL	2.0806 mL	10.4028 mL
20 mM	0.1040 mL	0.5201 mL	1.0403 mL	5.2014 mL
50 mM	0.0416 mL	0.2081 mL	0.4161 mL	2.0806 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.