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MG-132 (Z-Leu-Leu-Leu-al) is a 26S proteasome inhibitor (IC50=100 nM) that is cell-permeable and reversible. MG-132 acts as an autophagy activator and also induces apoptosis.

MG-T-19, a TIM-3 inhibitor (KD=0.26 μM), significantly inhibited the interaction of TIM-3 with PtdSer, CEACAM1, and Gal-9, and increased the production of TNF-α and IFN-γ in PBMCs, which reactivated the tumor-attacking ability of T cells.

MG-277 is a molecular glue compound transformed from PROTAC degradation agent, MG-277 potently inhibits tumor cell growth in a p53-independent manner.

(R)-MG-132 (Z-Leu-D-leu-leu-al) is the enantiomer of MG-132.

MG-115 (Z-LL-Nva-CHO) is a potent and reversible inhibitor of proteasome , with K i s of 21 nM and 35 nM for 20S and 26S proteasome, respectively. MG-115 specifically inhibit the chymotrypsin-like activity of the proteasome, induces p53-dependent apoptosis [1] [2] [3].

MG-262 is a reversible proteasome inhibitor with multiple biological activities (MGCD-162, Mills 2004) (Morrison et al., 2005, Li et al., 2006) (Tang et al., 2006, Zhang et al., 2007).

neuronal α7 nAChR antagonist

MG-101 (Calpain inhibitor I) is a cell-permeable and potent inhibitor of cysteine proteases including calpains and lysosomal cathepsins.

Mg(II)-EDTA (disodium tetrahydrate) is an ionic chelating agent suitable for preparing reagents used in ion-sensitive experiments.

Bortezomib (LDP 341) is a 20S proteasome inhibitor (Ki=0.6 nM) that is reversible and selective. Bortezomib has antitumor activity and inhibits NF-κB, which can disrupt the cell cycle and induce apoptosis.

Guaiapate has an antitussive and sedative effect.

Perphenazine (Trilafon) is a phenothiazine derivative and a dopamine antagonist with antiemetic and antipsychotic properties.

Sitravatinib malate is an orally bioavailable receptor inhibitor of tyrosine kinase (RTK) (IC50s of 1.5 nM, 2 nM, 2 nM, 5 nM, 6 nM, 6 nM, 8 nM, 0.5 nM, 29 nM, 5 nM, and 9 nM for Axl, MER, VEGFR3, VEGFR2, VEGFR1, KIT, FLT3, DDR2, DDR1, TRKA, TRKB, respectively.) , shows potent single-agent antitumor efficacy and enhances the activity of PD-1 blockade through promoting an antitumor immune microenvironment.

TP-10 is a selective inhibitor of PDE10A against other PDEs with IC50 of 0.8 nM.

Dihydroxyacetone phosphate hemimagnesium salt hydrate is also known as dihydroxyacetone phosphate or 3-hydroxy-2-oxopropyl phosphate. Dihydroxyacetone phosphate hemimagnesium salt hydrate is found in all organisms from bacteria to humans. In humans, Dihydroxyacetone phosphate hemimagnesium salt hydrate is involved in many enzymatic reactions. Dihydroxyacetone phosphate hemimagnesium salt hydrate has been studied for the treatment of lymphoma, large cell lymphoma, and diffuse lymphoma.

3-Methylguanine is a DNA damage product resulting from alkylation. It exhibits cytotoxicity by inhibiting DNA replication, leading to cell death. 3-Methylguanine is utilized to study the mechanisms of DNA damage by alkylating agents and the pathways involved in its repair.

Mocetinostat (MG0103) is an orally available HDAC inhibitor with most potency for HDAC1 (IC50: 0.15 μM), 2- to 10- fold selectivity against HDAC2/3/11.

Vanoxonin is a new thymidylate synthetase inhibitor.

Butixirate is a biochemical.

Amentoflavone (3',8''-Biapigenin), as a potent inhibitor of CYP3A4 and CYP2C9, can interact with many other medications. CYP3A4 and CYP2C9 are proteins used for drug metabolism in the body. Amentoflavone also is an inhibitor of human cathepsin B. It has antimalarial activity in trials significant affinities towards the Delta-1, kappa opioid receptors (as an antagonist) and binds to benzodiazepine receptors. Amentoflavone may be a potential lead for a new type of anti-inflammatory agents having the dual inhibitory activity of group II phospholipase A2 and cyclooxygenase. Amentoflavone and quercetin differentially exerted suppression of PGE2 biosynthesis via downregulation of COX-2/iNOS expression.

Sitravatinib (MGCD516) is an inhibitor targeting multiple RTKs involved in driving sarcoma cell growth, including c-Met, c-Kit, PDGFRα/β, PDGFR, and Axl.

Sertindole (Lu 23-174) is an atypical antipsychotic that binds to dopamine D2 receptors and serotonin (5-HT) receptor subtypes 5-HT1D, 5-HT2A, and 5-HT2C, with Kds of 2.7, 20, 0.14, and 6 nM, respectively.

PI-1840(IC50 = 27 nM)is a reversible and selective chymotrypsin-like (CT-L) inhibitor, with little proteasome proteolytic effects on trypsin-like (T-L) and postglutamyl-peptide-hydrolysis-like (PGPH-L).

2-Stearoyl-rac-glycerol is a natural product and monoglyceride, serving as an endogenous metabolite in mice and rats.