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BMS-984923

Name: BMS-984923
Brand: TargetMol
SKU: T38789
Rating: 4.5 (1 reviews)

🥰Excellent

Catalog No. T38789Cas No. 1375752-78-5

Alias BMS984923, BMS 984923

BMS-984923 is an orally available and blood-brain barrier permeable mGluR5 silencing allosteric modulator that inhibits β-amyloid oligomer-induced aberrant synaptic signaling, and can be used to study Alzheimer's disease.

BMS-984923

🥰Excellent

Purity: 99.46%

Catalog No. T38789Alias BMS984923, BMS 984923Cas No. 1375752-78-5

Product information is being updated, if you want to purchase, please click the bulk custom button.

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Batch Information

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Purity:99.46%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	BMS-984923 is an orally available and blood-brain barrier permeable mGluR5 silencing allosteric modulator that inhibits β-amyloid oligomer-induced aberrant synaptic signaling, and can be used to study Alzheimer's disease.
In vivo	BMS-984923 (7.5 mg/kg or 15 mg/kg, oral gavage, once) exhibited good oral bioavailability and BBB permeability in C57Bl6J male mice ( 7.5 mg/kg or 15 mg/kg, oral gavage, once); resulting in plasma concentrations exceeding 2 μM at 10 hours. Brain concentrations were almost as high as plasma concentrations when measured 3 hours after the 7.5 mg/kg oral dose [1].
Synonyms	BMS984923, BMS 984923

Chemical Properties

Molecular Weight	374.82
Formula	C₂₂H₁₅ClN₂O₂
Cas No.	1375752-78-5
Smiles	ClC1=C([C@@H]2[C@H](NC(=O)O2)C=3C=C(C#CC4=CC=CC=C4)C=NC3)C=CC=C1
Relative Density.	1.38 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 30 mg/mL (80.04 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.34 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6679 mL	13.3397 mL	26.6795 mL	133.3974 mL
5 mM	0.5336 mL	2.6679 mL	5.3359 mL	26.6795 mL
10 mM	0.2668 mL	1.3340 mL	2.6679 mL	13.3397 mL
20 mM	0.1334 mL	0.6670 mL	1.3340 mL	6.6699 mL
50 mM	0.0534 mL	0.2668 mL	0.5336 mL	2.6679 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc