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BMS-984923

Name: BMS-984923
Brand: TargetMol
SKU: T38789
Rating: 4.5 (1 reviews)

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Catalog No. T38789Cas No. 1375752-78-5

Alias BMS984923, BMS 984923

BMS-984923 is an orally available and blood-brain barrier permeable mGluR5 silencing allosteric modulator that inhibits β-amyloid oligomer-induced aberrant synaptic signaling, and can be used to study Alzheimer's disease.

BMS-984923

🥰Excellent

Purity: 99.46%

Catalog No. T38789Alias BMS984923, BMS 984923Cas No. 1375752-78-5

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Purity:99.46%

Appearance:Solid

Color:Yellow

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	BMS-984923 is an orally available and blood-brain barrier permeable mGluR5 silencing allosteric modulator that inhibits β-amyloid oligomer-induced aberrant synaptic signaling, and can be used to study Alzheimer's disease.
In vivo	BMS-984923 (7.5 mg/kg or 15 mg/kg, oral gavage, once) exhibited good oral bioavailability and BBB permeability in C57Bl6J male mice ( 7.5 mg/kg or 15 mg/kg, oral gavage, once); resulting in plasma concentrations exceeding 2 μM at 10 hours. Brain concentrations were almost as high as plasma concentrations when measured 3 hours after the 7.5 mg/kg oral dose [1].
Synonyms	BMS984923, BMS 984923

Chemical Properties

Molecular Weight	374.82
Formula	C₂₂H₁₅ClN₂O₂
Cas No.	1375752-78-5
Smiles	ClC1=C([C@@H]2[C@H](NC(=O)O2)C=3C=C(C#CC4=CC=CC=C4)C=NC3)C=CC=C1
Relative Density.	1.38 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 30 mg/mL (80.04 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.34 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6679 mL	13.3397 mL	26.6795 mL	133.3974 mL
5 mM	0.5336 mL	2.6679 mL	5.3359 mL	26.6795 mL
10 mM	0.2668 mL	1.3340 mL	2.6679 mL	13.3397 mL
20 mM	0.1334 mL	0.6670 mL	1.3340 mL	6.6699 mL
50 mM	0.0534 mL	0.2668 mL	0.5336 mL	2.6679 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc