BIO

GSK 3 Inhibitor IX (6-BIO) is a selective reversible, ATP-competitive inhibitor of GSK-3α/β and CDK1-cyclinB complex. It inhibits (GSK-3α/β)/CDK1/CDK5 activity with IC50 values of 5 nM/320 nM/83 nM, respectively.

BIO-32546 (S-isomer) is a highly potent regulator of autotaxin (ATX) with an IC50 value of 1 nM.

bio-THZ1 is a biotinylated version of THZ1, a selective and irreversibly covalent CDK7 inhibitor (IC50: 3.2 nM).

BIO-1211 is a more potent inhibitor of α4β1 (VLA-4, IC50 = 4 nM) over α4β7(IC50 = 2 μM).

BIO399 is an agonist of the RORγt inverse.

BIO592 is a modulator of RORγt. BIO592 triggers inverse agonism of RORγ.

BIO-7662 is an effective and highly selective antagonist of α4β1 integrin.

BIO5192 hydrate is a selective and potent integrin α4β1 (VLA-4) inhibitor (Kd < 10 pM). The compound selectively binds to α4β1 (IC50 = 1.8 nM) over various other integrins and results in a 30-fold increase in mobilization of murine hematopoietic stem and progenitors (HSPCs) over basal levels[1][2].

(E/Z) - BIO-acetoxime is effective and selective GSK-3 α/β Inhibitors. For GSK-3 α/β, CDK5/p25, CDK2/cyclin A and CDK1/cyclin B, IC50 are 10nM, 2.4 μM, 4.3 μ M, 63 μ M, respectively.

BIO-acetoxime (GSK-3 Inhibitor X) is a potent dual GSK3α/β inhibitor with IC50 of 10 nM, >240-fold selectivity over CDK5/p25, CDK2/cyclin A and CDK1/cyclin B.

Bio-AMS (TFA) is a potent inhibitor of bacterial biotin protein ligase, demonstrating selective efficacy against Mycobacterium tuberculosis (Mtb) by inhibiting fatty acid and lipid biosynthesis [1].

Bio-AMS is a potent inhibitor of bacterial biotin protein ligase, exhibiting selective activity against Mycobacterium tuberculosis (Mtb) and disrupting fatty acid and lipid biosynthesis [1] [2].

BIO-013077-01 is a potent TGFbeta family type I receptors antagonist.

Bio-17-ATP serves as a substrate for AMPylation assays [1].

BIO-7488, a potent and selective IRAK4 inhibitor, is orally active and penetrates the CNS, exhibiting an IC50 of 0.6 nM for IRAK4 and > 30 μM for hERG [1].

PLLA5000-PEG5000-BIO is a polylactic acid derivative that can form micelles in water. Additionally, PLLA5000-PEG5000-BIO is capable of binding tightly with avidin or streptavidin, making it suitable for protein labeling. This compound is also applicable in drug delivery research.

PLLA5000-PEG2000-BIO is a derivative of polylactic acid that can form micelles in water. Additionally, PLLA5000-PEG2000-BIO binds tightly with avidin or streptavidin, making it suitable for protein labeling. It is also applicable in drug delivery research.

PLLA5000-PEG1000-BIO is a polylactic acid derivative capable of forming micelles in water. Additionally, PLLA5000-PEG1000-BIO can tightly bind with avidin or streptavidin, making it suitable for protein labeling. This compound is also applicable in drug delivery research.

PLLA4000-PEG5000-BIO is a polylactic acid derivative known for forming micelles in water. In addition, PLLA4000-PEG5000-BIO has a strong binding affinity to avidin or streptavidin, making it suitable for protein labeling. This compound is also utilized in research related to drug delivery.

PLLA4000-PEG2000-BIO is a polylactic acid derivative that can form micelles in water. Additionally, PLLA4000-PEG2000-BIO binds tightly with (strept)avidin, making it useful for protein labeling. This compound is also employed in studies related to drug delivery.

PLLA4000-PEG1000-BIO is a polylactic acid derivative that can form micelles in water. Furthermore, PLLA4000-PEG1000-BIO binds tightly with avidin or streptavidin, making it suitable for protein labeling. It is also applicable in drug delivery research.

PLLA3000-PEG5000-BIO is a polylactic acid derivative capable of forming micelles in water. Additionally, PLLA3000-PEG5000-BIO exhibits a strong binding affinity for avidin or streptavidin, making it suitable for protein labeling. This compound is also applicable in drug delivery research.

PLLA3000-PEG2000-BIO is a polylactic acid derivative that can form micelles in water. Additionally, it binds tightly with avidin or streptavidin, making it suitable for protein labeling. PLLA3000-PEG2000-BIO is also applicable in drug delivery research.

PLLA3000-PEG1000-BIO is a polylactic acid derivative that forms micelles in water. Additionally, it can bind strongly with avidin or streptavidin, making it suitable for protein labeling. This compound is also applied in drug delivery research.