specific

Eplerenone (CGP 30083) is an aldosterone receptor antagonist and potassium-sparing diuretic used in the therapy of hypertension. Eplerenone therapy has been associated with transient elevations in serum aminotransferase levels, but has yet to be linked to cases of clinically apparent drug induced liver disease.

Gadolinium chloride is a calcium-sensing receptor (CaSR) agonist

Dofetilide (UK 68789) is a sulfonamide class III antiarrhythmic agent and potassium channel blocker. Dofetilide selectively blocks cardiac ion channels of the rapid component of the delayed rectifier potassium current Ikr. This antiarrhythmic agent prolongs cardiac action potential duration and effective refractory period due to delayed repolarization without affecting conduction velocity. This results in a normal sinus rhythm. Dofetilide is used in the treatment of atrial fibrillation and flutter.

CU-T12-9 is a potent TLR1/2 agonist(EC50 of 52.9 nM in HEK-Blue hTLR2 SEAP assay). It acts by activating the NFkB pathway, upregulating proinflammatory cytokines, and enhancing TLR1 and TLR2 dimerization.CU-T12-9 activates both the innate and the adaptive immune systems. CU-T12-9 selectively activates the TLR1/2 heterodimer, not TLR2/6. CU-T12-9 signals through NF-κB and invokes an elevation of the downstream effectors TNF-α, IL-10, and iNOS.

VU0071063 is a Kir6.2/SUR1 activator.

GW 441756 is a specific Tropomyosin-related kinase A (TrkA) inhibitor with an IC50 value of 2 nM.

AMG-47a is a potent inhibitor of Lck and T cell proliferation. AMG-47a could promote the degradation of the KRAS oncoprotein. AMG-47a selectively reduced the levels of EGFP-KRASG12V protein but did not affect EGFP protein in cells.

DDO-5936 is a potent and specific inhibitor of the protein-protein interaction (PPI) between HSP90 and Cdc37.

Lysine-specific demethylase inhibitor (1C) (LSD inhibitor (1C)) is an inhibitor of LSD1, a repressive demethylase selective for histone H3 lysine 4 (H3K4).1,2LSD inhibitor (1C) inhibits LSD1 activity by 85.9% when used at a concentration of 10 μM.1It increases the level of H3K4 methylation, including H3K4me1 and H3K4me2 but not H3K9me2 levels, in HCT116 human colon carcinoma cells.2LSD inhibitor (1C) also induces re-expression of the Wnt signaling pathway proteins secreted frizzle-related protein 1 (SFRP1), SFRP4, and SFRP5, as well as the transcription factor GATA5, which are aberrantly silenced in HCT116 cells.

Anti-SARS-CoV-2 Omicron (BA.4/BA.5/BA.2.75) Spike RBD Specific Antibody (3M568) is a mouse (variable region) / human (kappa / IgG1 constant) chimeric monoclonal antibody targeting SARS-CoV-2 SARS-CoV-2 Omicron (BA.4/BA.5/BA.2.75) Spike RBD Specific.

Anti-SARS-CoV-2 Alpha Spike RBD Specific Antibody (4J592) is a mouse (variable region) / human (kappa / IgG1 constant) chimeric monoclonal antibody targeting SARS-CoV-2 SARS-CoV-2 Alpha Spike RBD Specific.

Anti-SARS-CoV-2 Delta Spike RBD Specific Antibody (2J642) is a mouse (variable region) / human (kappa / IgG1 constant) chimeric monoclonal antibody targeting SARS-CoV-2 SARS-CoV-2 Delta Spike RBD Specific.

CCK1-specific peptide substrate is a bioactive peptide. [The peptide sequence is based on Ser7-phosphorylated rabbit muscle glycogen synthase.] It serves as a peptide substrate for casein kinase I (CK1), which phosphorylates Ser10. In vivo, Ser7 is phosphorylated by PKA.

Neuron-specific enolase, Human (EC 4.2.1.11), is an enolase enzyme that serves as a biomarker for traumatic brain injury (TBI), stroke following cardiac arrest, hypoxic encephalopathy, and acute spinal cord injury (SCI).

α-Galactosidase, positionally specific, Escherichia coli (EC 3.2.1.22), is a glycoside hydrolase enzyme that catalyzes the hydrolysis of α-galactosyl residues from the termini of glycolipids and glycoproteins. It exists in two recombinant forms known as α-galactosidase (INN) and β-galactosidase (INN).

Specific PXR antagonist 70 is a selective pregnane X receptor (PXR) antagonist with an IC50 of 540 nM and Ki of 390 nM for human PCR and enhances the chemosensitivity of cancer cells.

The ubiquitin speci c protease 3 USP3 is a deubiquitinating enzyme for uH2A and uH2B.

Prostate specific antigen protein (human) is a serine protease produced by the prostate epithelium. It is utilized in prostate cancer research.

Itaconate-alkyne (ITalk) is a bioorthogonal probe for quantitative, site-specific chemoproteomic profiling of itaconate in inflammatory macrophages, facilitating biochemical evaluation and proteomic analysis of its direct targets.

Vacquinol-1 is an MKK4 activator, which rapidly and selectively induces glioma cell death.

ALK inhibitor 1 is a selective ALK kinase inhibitor.

Pulrodemstat benzenesulfonate (CC-90011 benzenesulfonate) is a potent and orally active inhibitor of lysine specific demethylase-1 (LSD1) with anticancer activity.

LSD1-IN-7 Methylbenzenesulfonate is a potent and orally active inhibitor of lysine specific demethylase-1 (LSD1) with anticancer activity.

induces phenotypic differentiation