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Boc-Lys(Ac)-AMC

Name: Boc-Lys(Ac)-AMC
Brand: TargetMol
SKU: T36578
Price: 42 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T36578Cas No. 233691-67-3

Alias Boc-L-Lys(Ac)-AMC

Boc-Lys(Ac)-AMC (Boc-L-Lys(Ac)-AMC) is a synthetic substrate coupled to an HDAC-specific fluorophore (Ex/Em = 355 nm/460 nm).

Boc-Lys(Ac)-AMC

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Purity: 99.87%

Catalog No. T36578Alias Boc-L-Lys(Ac)-AMCCas No. 233691-67-3

Boc-Lys(Ac)-AMC (Boc-L-Lys(Ac)-AMC) is a synthetic substrate coupled to an HDAC-specific fluorophore (Ex/Em = 355 nm/460 nm).

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$42	-	In Stock
10 mg	$68	-	In Stock
25 mg	$128	-	In Stock
50 mg	$187	-	In Stock
100 mg	$275	-	In Stock
200 mg	$397	-	In Stock
1 mL x 10 mM (in DMSO)	$46	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.87%

Appearance:Solid

Color:White

Resource Download

COA HNMR HPLC MS

Product Introduction

Bioactivity

Description	Boc-Lys(Ac)-AMC (Boc-L-Lys(Ac)-AMC) is a synthetic substrate coupled to an HDAC-specific fluorophore (Ex/Em = 355 nm/460 nm).
In vitro	HDACs act by catalyzing the deacetylation reaction of the substrate Boc-Lys(Ac)-AMC. Upon addition of trypsin-containing development reagents, the deacetylation products are converted into quantifiable fluorescent markers that can be used both in screening methods and to help identify potential HDAC inhibitors. [1]
Synonyms	Boc-L-Lys(Ac)-AMC

Chemical Properties

Molecular Weight	445.51
Formula	C₂₃H₃₁N₃O₆
Cas No.	233691-67-3
Smiles	CC=1C=2C(=CC(NC([C@@H](NC(OC(C)(C)C)=O)CCCCNC(C)=O)=O)=CC2)OC(=O)C1
Relative Density.	1.209 g/cm3 (Predicted)
Sequence	Boc-Lys(Ac)-AMC
Sequence Short	X

Storage & Solubility Information

Storage

keep away from direct sunlight,keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (179.57 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2446 mL	11.2231 mL	22.4462 mL	112.2309 mL
5 mM	0.4489 mL	2.2446 mL	4.4892 mL	22.4462 mL
10 mM	0.2245 mL	1.1223 mL	2.2446 mL	11.2231 mL
20 mM	0.1122 mL	0.5612 mL	1.1223 mL	5.6115 mL
50 mM	0.0449 mL	0.2245 mL	0.4489 mL	2.2446 mL
100 mM	0.0224 mL	0.1122 mL	0.2245 mL	1.1223 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc