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GT-653
🥰Excellent
Catalog No. T209891
GT-653 is a PROTAC degrader targeting lysine-specific demethylase 5B (KDM5B). It induces the degradation of KDM5B via ubiquitin-proteasome pathways, achieving a degradation rate of 68.35% at a concentration of 10 μM. Additionally, GT-653 upregulates H3K4me3 levels and activates type I interferon signaling pathways in prostate cancer cells 22RV1.
GT-653
GT-653
🥰Excellent
Catalog No. T209891
GT-653 is a PROTAC degrader targeting lysine-specific demethylase 5B (KDM5B). It induces the degradation of KDM5B via ubiquitin-proteasome pathways, achieving a degradation rate of 68.35% at a concentration of 10 μM. Additionally, GT-653 upregulates H3K4me3 levels and activates type I interferon signaling pathways in prostate cancer cells 22RV1.
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Product Introduction
Bioactivity
Chemical Properties
| Description | GT-653 is a PROTAC degrader targeting lysine-specific demethylase 5B (KDM5B). It induces the degradation of KDM5B via ubiquitin-proteasome pathways, achieving a degradation rate of 68.35% at a concentration of 10 μM. Additionally, GT-653 upregulates H3K4me3 levels and activates type I interferon signaling pathways in prostate cancer cells 22RV1. |
| Formula | C32H27N7O9 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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