m 1

Niraparib metabolite M1 HCl is the active metabolite of Niraparib, as a novel targeted ADP ribose polymerase (PARP) inhibitor, it can competitively inhibit PARP1 and PARP2 to block the DNA repair mechanism of tumor cells and thus effectively inhibit the growth and proliferation, which is commonly used in the study of ovarian cancer, fallopian tube cancer and primary peritoneal cancer, and is commonly used in the study of ovarian, fallopian tube and primary peritoneal cancers.

AR-13324 M1 metabolite is a hydrolysis metabolite of AR-13324 mesylate.

Lopinavir Metabolite M-1, an active metabolite of Lopinavir, effectively inhibits the HIV protease enzyme with a Ki value of 0.7 pM, demonstrating notable antiviral properties in [in vitro] studies.

Mitochondrial fusion promoter M1, a modulator of mitochondrial dynamics, enhances mitochondrial function and cellular respiration, and has shown efficacy in reducing brain and cardiac damage in rats suffering from cardiac ischemia/reperfusion injury.

Platycoside M1 is a natural product for research related to life sciences. The catalog number is TN4806 and the CAS number is 917482-67-8.

(+/-)-Gomisin M1 exhibits potent anti-HIV activity, with EC50 and therapeutic index (TI) values of <0.65 microM and >68, respectively.

Virginiamycin M1 (Pristinamycin IIA) is a macrocyclic lactone peptide antibiotic and is a member of the streptogramin A group of antibiotics.

Zafirlukast metabolite M1 (compound 15) is an inhibitor used in the treatment of asthma and other allergic pulmonary conditions, effectively antagonizing leukotriene activity.

MBA-m1 is an MLKL inhibitor that suppresses necroptosis in Mlkl−/−NIH-3T3 cells. Additionally, MBA-m1 alleviates disease conditions in mouse models of dermatitis and abdominal aortic aneurysm induced by MLKL.

M1/M4 muscarinic agonist 1 (Compound 41) is a selective muscarinic M4/M1 agonist with EC50 values of 14 nM for M4 receptors and 55 nM for M1 receptors. This compound is utilized in research related to psychiatric disorders, including schizophrenia and delusional disorders.

Compound 43, known as M1/M2/M4 muscarinic agonist 2, functions as an mAChR M1/M2/M4 agonist with respective EC50 values of 30 nM, 200 nM, and 6.2 nM.

M1 ligand 1 (compound 3b-b) is a N-desmethyl analog of the arecoline derivative, acting as a muscarinic acetylcholine receptor M1 ligand and usable as a PET (positron emission tomography) radiotracer [1].

Antibiotic MA 144M1 is an anthracycline glycoside that inhibits the growth of gram-positive bacteria, e.g. Staphyococcus aureaus, Bacillus subtilis and Sarcina lutea, and inhibits the growth of animal tumors such as leukemia L 1210, P 388 and sarcoma 180. It's produced by fermentation of MA 144-producing strains of streptomyces and by the chemical or enzymatic conversion of aclacinomycin A or cinerubin A.

BmK-M1, a scorpion-derived toxin, consists of a 64-amino acid polypeptide stabilized by four disulfide bridges. This compound functions as an inhibitor of the Na+ channel, classifying it as both a cardiotoxin and a neurotoxin [1].

Compound 40 is a selective M1/M4 muscarinic antagonist with an IC50 of 19 nM for M1 receptors and 42 nM for M4 receptors [1].

Compound 42, also known as M1/M2/M4 muscarinic agonist 1, is a muscarinic M4/M1/M2 agonist exhibiting EC50 values of 6.5, 26, and 210 nM for M4, M1, and M2 respectively. This compound is utilized in research focused on mental disorders, including schizophrenia and delusion [1].

Muscarinic agonist 3 (compound 45) is a muscarinic mAChR M1/M2/M4 agonist with EC50 values of 3.2 nM, 32 nM, and 1.7 nM, respectively [1].

Compound 44, identified as an M1/M4 muscarinic agonist, exhibits potent activity with EC50 values of 31 nM at M1 and 9.3 nM at M4 mAChRs, respectively [1].

Anti-Mouse MHC Class I (H-2) Antibody (M1/42.3.9.8) is a rat-derived IgG2a, κ antibody inhibitor specifically targeting mouse MHC Class I.

Virginiamycin M1 (Standard) is the standard substance of Virginiamycin M1, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Virginiamycin M1 (Pristinamycin IIA) is a macrocyclic lactone peptide antibiotic and is a member of the streptogramin A group of antibiotics.

CEF1, Influenza Matrix Protein M1 (58-66), is an epitope derived from the matrix protein of the influenza A virus. GILGFVFTL is an HLA-A2-restricted epitope from this matrix M1 protein.

Micafungin metabolite M1 is an active metabolite of Micafungin, generated through metabolism by arylsulfatase, and exhibits antifungal activity. It can be utilized in research on deep fungal infections caused by Candida species (Candidiasis) and Aspergillus species (Aspergillosis).

Nef-M1 (Nef-Motif-1) is an antagonist peptide targeting CXCR4 and an apoptosis (apoptosis) inducer derived from the myristoylated protein encoded by the HIV nef gene. Nef-M1 inhibits tumor angiogenesis and epithelial-mesenchymal transition (EMT) by activating the apoptotic pathway through increased levels of caspase-3 in cancer cells. Additionally, it suppresses VEGF-A, p-GSK-3β, and vimentin while enhancing E-cadherin, thereby hindering angiogenesis and EMT processes. Nef-M1 is applicable in colorectal cancer and breast cancer research.

M1-20 is a CDK1 inhibitor. It promotes the ubiquitination of CDK1 through the CUL4-DDB1-DCAF1 complex, leading to its degradation via the proteasome pathway. M1-20 inhibits the formation of the CDK1/CCNB1 complex and exhibits significant anticancer activity against spontaneous breast cancer in the FVB/N MMTV-PyVT mouse model.