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Results for "

2(biotinamido)1,3bis(c1peg1acid)

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    6093
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    1
    TargetMol | inventory
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    779
    TargetMol | natural
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    2
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    691
    TargetMol | natural
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2-(Biotin-amido)-1,3-bis-(C1-PEG1-acid)
T140142086689-02-1
2-(Biotin-amido)-13-bis(carboxylethoxy)propane is a polyethylene glycol (PEG)-based PROteolysis TArgeting Chimera (PROTAC) linker used in the synthesis of PROTACs[1].
  • Inquiry Price
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PROTAC BRD4 ligand-1
T125512313230-51-0In house
PROTAC BRD4 ligand-1, a component of Protac GNE-987, is a ligand for BRD4 and acts as an inhibitor of BET.
  • $125
In Stock
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TargetMol | Inhibitor Hot
(+)-JQ-1
T21101268524-70-4
(+)-JQ-1 (JQ1) is a specific, reversible BET bromine domain inhibitor that targets BRD4 (1 2) with IC50 values of 77 33 nM. (+)-JQ-1 induces cell autophagy and inhibits cell proliferation.
  • $30
In Stock
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TargetMol | Inhibitor Hot
TargetMol | Citations Cited
Androgen receptor antagonist 1
T103201338812-36-4In house
Androgen receptor antagonist 1, an orally available full androgen receptor antagonist (IC50: 59 nM), is utilized in the synthesis of PROTAC AR degraders, achieving 24% and 47% AR protein degradation in LNCaP cells at concentrations of 1 μM and 10 μM, respectively.
  • $1,520
6-8 weeks
Size
QTY
1,2-Bis(2-iodoethoxy)ethane
T1731936839-55-1
1,2-Bis(2-iodoethoxy)ethane is a PEG-based PROTAC linker used in the synthesis of MT802 and SJF620, which are potent PROTAC BTK degraders with DC50s of 1 nM and 7.9 nM, respectively [1].
  • $29
In Stock
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TargetMol | Inhibitor Sale
1-Bromo-6-chlorohexane
T407286294-17-3
1-Bromo-6-chlorohexane (Hexane, 1-bromo-6-chloro-) is used as PROTAC linker.
  • $35
In Stock
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TargetMol | Inhibitor Sale
N-Boc-4-pentyne-1-amine
T18391151978-50-6
N-Boc-4-pentyne-1-amine is an alkyl chain-based PROTAC linker compound used in the synthesis of PROTAC MG-277 [1].
  • $29
In Stock
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SMARCA-BD ligand 1 for Protac
T138481997319-92-2In house
SMARCA-BD ligand 1 for Protac is a compound that binds to SMARCA2, the BAF ATPase subunit, utilizing Protac technology to degrade SMARCA2.
  • $197
In Stock
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TargetMol | Inhibitor Sale
2-Phthalimidehydroxy-acetic acid
T17330134724-87-1
2-Phthalimidehydroxy-acetic acid is an alkyl chain-based PROTAC linker utilized in PROTAC synthesis.
  • $42
In Stock
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AR antagonist 1
T103591818885-54-9
AR antagonist 1 is a potent antagonist of the androgen receptor. It binds to E3 ligase ligands with weak binding affinities to VHL protein in the synthesis of PROTAC ARD-266.
  • $78
In Stock
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JQ-1 (carboxylic acid)
T5443202592-23-2
JQ-1 (carboxylic acid) is a cell-permeable BRD4 inhibitor with IC50s of 77 nM for BRD4(1) and 33 nM for BRD4(2)
  • $64
In Stock
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TargetMol | Citations Cited
dCBP-1
T93702484739-25-3
dCBP-1 is a chemical degrader of p300 CBP. dCBP-1 hijacks the E3 ubiquitin ligase CRBN for selective degradation of p300 CBP. Degradation of p300 CBP by dCBP-1 leads to effective multiple myeloma cell killing.
  • $96
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TargetMol | Inhibitor Sale
TargetMol | Citations Cited
PROTAC BRAF-V600E degrader-1
T87452417296-84-3
PROTAC BRAF-V600E degrader-1 (Compound 23) selectively induces degradation of BRAF-V600E but not wildtype BRAF.
  • $115
In Stock
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TargetMol | Inhibitor Sale
BRD7-IN-1
T176972448414-48-8
BRD7-IN-1, a modified derivative of BI7273 (BRD7 9 inhibitor), forms PROTAC VZ185 via linkage to a VHL ligand, demonstrating potent activity against BRD7 9 with DC50 values of 4.5 and 1.8 nM, respectively [1].
  • $100
In Stock
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TargetMol | Inhibitor Sale
Homo-PROTAC cereblon degrader 1
T137212244520-98-5
Homo-PROTAC cereblon degrader 1 is a highly potent and efficient cereblon (CRBN) degrader with only minimal effects on IKZF1 and IKZF3.
  • $228
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SMARCA-BD ligand 1 for Protac dihydrochloride
T138902369053-68-7
SMARCA-BD ligand 1 for Protac dihydrochloride binds to the BAF ATPase subunit SMARCA2 and is used for degrading SMARCA2 based on PROTAC.
  • $61
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Homo-PROTAC pVHL30 degrader 1
T137222244684-49-7
Homo-PROTAC pVHL30 degrader 1 is a potent PROTAC-based degrader of pVHL30.
  • $29
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PROTAC ERRα ligand 1
T151911264754-13-3
PROTAC ERRα ligand 1 is an estrogen-related receptor α (ERRα) antagonist with IC50 values of 0.04 μM for ERRα and 2.8 μM for ERRγ.
  • $30
In Stock
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TargetMol | Inhibitor Sale
CRBN modulator-1
T88242407829-65-4
CRBN modulator-1 (WUN29654) is a Thalidomide analog and CRBN modulator,has an IC50 of 3.5 μM and a Ki of 0.98 μM.
  • $33
In Stock
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TargetMol | Inhibitor Sale
PROTAC BcI-2/BcI-xI Degrader-1
T882003034200-49-9
  • Inquiry Price
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PROTAC AR/AR-V7 degrader-1
T872562841308-96-9
PROTAC AR AR-V7 degrader-1 (27c) serves as a dual degrader targeting both AR and AR-V7, showcasing DC50 values of 2.67 and 2.64 μM for AR and AR-V7, respectively. It effectively induces apoptosis (Red: AR antagonist; Blue: E3 ligase ligand; Black: linker) [1].
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PROTAC ATR degrader-1
T872572925916-30-7
PROTAC ATR degrader-1 (compound ZS-7) serves as a powerful PROTAC degrader targeting ataxia telangiectasia and Rad3-related (ATR), exhibiting a DC50 of 0.53 μM. This compound is significant in the field of cancer research [1].
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PROTAC Hsp90α degrader 1
T79323
Compound X10g (PROTAC Hsp90α degrader 1) is a selective agent targeting Hsp90α for degradation and is utilized in breast cancer research. It demonstrates inhibitory effects on the proliferation of breast cancer cell lines, MDA-MB-231, MDA-MB-468, MCF-7, and MX-1, with respective IC50 values of 51.48 μM, 16.46 μM, 8.93 μM, and 11.95 μM [1].
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FMF-06-098-1
T823852769753-07-1
FMF-06-098-1 is a multitargeted depressant that promotes the degradation of various kinases including AAK1, ABL2, AURKA, AURKB, BUB1B, CDC7, CDK1, CDK12, CDK13, CDK2, CDK4, CDK6, CDK7, CDK9, CHEK1, CSNK1D, EPHA1, PAK, FGFR1, GAK, IRAK4, ITK, LIMK2, MAP4K2, MAP4K3, MAPK6, MAPK7, MARK4, MELK, PKN3, PLK4, PRKAA1, PTK2, PTK6, RPS6KA4, SGK2, STK35, TNK2, UHMK1, ULK1, and WEE1 [1].
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1-Cbz-azetidine-3-carboxylic acid
T6660997628-92-7
1-Cbz-azetidine-3-carboxylic acid (catalog number: T66609, CAS number: 97628-92-7) is a valuable organic compound for life sciences research.
    7-10 days
    Inquiry
    PROTAC STING Degrader-1
    T748962762552-74-7
    PROTAC STING Degrader-1 (Compound SP23) is a STING-targeted PROTAC degrader with a DC50 of 3.2 μM, demonstrating anti-inflammatory activity [1].
    • $338
    35 days
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    BacPROTAC-1
    T75171
    BacPROTAC-1, a potent mSA BacPROTAC degrader, exhibits high affinity for both mSA and the N-terminal domain (NTD) of ClpC, with dissociation constants (K D) of 3.9 μM and 2.8 μM, respectively [1].
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    PROTAC Axl Degrader 1
    T74353
    PROTAC Axl Degrader 1 is a potent and selective compound with an IC50 of 0.92 µM, exhibiting in vitro anti-proliferative and anti-migratory activities, and inducing mehuosis [1].
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    PROTAC EZH2 Degrader-1
    T746022641601-67-2
    PROTAC EZH2 Degrader-1 (Compound 150d) is a potent inhibitor that effectively suppresses EZH2 methyltransferase activity, with an IC50 of 2.7 nM. EZH2 plays a critical role in various tumorigenesis and development processes [1].
    • $215
    7-10 days
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    HEMTAC CDK4/6 degrader 1
    T750292821803-61-4
    HEMTAC CDK4 6 degrader 1 is a PROTAC connected by ligands for HSP90 and CDK4 6 with a ( K_d ) value of 35.7 μM. It induces CDK4 6 degradation in B16F10 melanoma cells, arrests the cell cycle at the G0 G1 phase, and induces apoptosis. HEMTAC CDK4 6 degrader 1 can be used in cancer research [1].
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    BCL6 PROTAC 1
    T738692257479-54-0
    BCL6 PROTAC 1 is a selective B-cell lymphoma 6 (BCL6) proteolysis targeting chimera (PROTAC) that inhibits the BCL6 cell reporter with an IC50 of 8.8 µM and significantly degrades BCL6 in diffuse large B-cell lymphoma (DLBCL) cell lines, making it valuable for tumor-related research [1].
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    PROTAC PARP/EGFR ligand 1
    T741732661609-57-8
    PROTAC PARP EGFR ligand 1 is a potent compound used in developing dual PARP-EGFR degraders via Proteolytic Targeting Chimera (PROTAC) technology [1].
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    dTAGV-1-NEG
    T362552451573-87-6
    Negative control for dTAGV-1.
    • $1,280
    35 days
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    PROTAC CDK9 ligand-1
    T399972411021-95-7
    PROTAC CDK9 ligand-1, a CDK9 ligand, is used in the synthesis of PROTACs.
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    Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2
    T400942435572-48-6
    Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2 is a synthetic conjugate that combines a Thalidomide-based cereblon ligand and a linker, commonly utilized in PROTAC technology. This compound serves as a connector between the target protein and the E3 ligase, facilitating targeted protein degradation.
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    ZXH-1-161
    T630102407654-51-5
    ZXH-1-161 is a potent regulator of cereblon (CRBN) with an IC50 of 39 μM in wild-type MM1.S cells, selectively degrading GSPT1, and is useful for studying multiple myeloma.
    • $1,490
    6-8 weeks
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    PROTAC MDM2 Degrader-1
    T186312249944-98-5
    PROTAC MDM2 Degrader-1 is a chemical compound that employs PROTAC technology to degrade MDM2, comprising a highly effective MDM2 inhibitor, a linker, and the MDM2 ligand for E3 ubiquitin ligase[1].
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    ERRα Ligand-Linker Conjugates 1
    T17941
    ERRα Ligand-Linker Conjugates 1 refers to a chemical compound that consists of a ligand targeting estrogen-related receptor alpha (ERRα), and a PROTAC linker that facilitates the recruitment of E3 ligases MDM2. It finds utility in the synthesis of a range of PROTACs, including one known as PROTAC ERRalpha Degrader-1. With its capability to induce degradation of ERRα, PROTAC ERRalpha Degrader-1 functions as an ERRα degrader[1].
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    PROTAC Her3-binding moiety 1
    T138411603845-36-8
    PROTAC Her3-binding moiety 1 is a Her3 Ligand for PROTAC.
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    PROTAC IRAK4 ligand-1
    T138432357108-39-3
    PROTAC IRAK4 ligand-1 is a synthetic ligand targeting interleukin-1 receptor-associated kinase 4 (IRAK4).
      7-10 days
      Inquiry
      NAMPT inhibitor-linker 1
      T184772241019-57-6
      NAMPT inhibitor-linker 1, a drug-linker conjugate for ADC, integrates an NAMPT inhibitor (as a payload) with a linker. In the formulation of ADC-3, it pairs with an anti-c-Kit monoclonal antibody, demonstrating strong efficacy against c-Kit expressing cell lines, specifically GIST-T1 and NCI-H526, where it exhibits IC50 values of <3 pM and 9 pM, respectively.
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      N-Boc-N-bis(PEG2-acid)
      T183922054339-01-2
      N-Boc-N-bis(PEG2-acid) is a PEG-based linker for PROTACs that joins two essential ligands, facilitating selective protein degradation via the ubiquitin-proteasome system within cells.
      • $41
      5 days
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      C6-Bis-phosphoramidic acid diethyl ester
      T177071446282-35-4
      C6-Bis-phosphoramidic acid diethyl ester is an alkyl chain-derived PROTAC linker suitable for PROTAC synthesis [1].
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      Bis-PEG21-acid
      T17623
      Bis-PEG21-acid is a PEG-based linker for PROTACs that connects two crucial ligands, facilitating the formation of PROTAC molecules and enabling selective protein degradation through the ubiquitin-proteasome system within cells.
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      Tetraethyl butane-​1,​4-​diylbis(phosphoramid​ate)
      T17050720707-93-7
      Tetraethyl butane- 1, 4- diylbis(phosphoramid ate) is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].
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      PROTAC CDK2/9 Degrader-1
      T125522408641-24-5
      PROTAC CDK2/9 Degrader-1 is a potent CDK2 and CDK9 dual degrader(DC50 of 62 nM and 33 nM).
      • Inquiry Price
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      N-Benzyl-N-bis(PEG3-acid)
      T183872093154-03-9
      N-Benzyl-N-bis(PEG3-acid) is a polyethylene glycol (PEG)-based PROTAC linker that facilitates the synthesis of PROTACs[1].
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      PROTAC BRD2/BRD4 degrader-1
      T18598
      PROTAC BRD2 BRD4 degrader-1 (compound 15) is a potent, selective degrader of BET proteins BRD4 and BRD2, achieving rapid, reversible, and unexpectedly selective elimination compared to BRD3. It effectively suppresses solid tumors with minimal cytotoxic effects and comprises a BET inhibitor, a connecting linker, and thalidomide as the ligand for cereblon (CRBN) cullin 4A[1].
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