gc

GC7 Sulfate is a potent inhibitor of deoxyhypusine synthase (DHS). Eukaryotic translation initiation factor 5A2 (eIF5A2) is the only known substrate for DHS, so GC7 inhibits the activation of eIF5A2 by inhibiting DHS activity.

GC 14 is a selective thyroid hormone receptor antagonist with IC50 values of 200 nM for hTRα and 35 nM for hTRβ.

GC 10284 is an agent of pesticide.

(±)-GC242 is a profluorescent RAMOSUS3 (RMS3) probe with strigalactone-like biological activity.

GC376 is an inhibitor of 3C-like proteases (3CLpro) with IC50 values range from 0.49~4.35 μM.

Org GC 94 is a serotonin antagonist; anti-migraine.

GC-204 is a selective inhibitor of carbonic anhydrase ix (caix)

GC-072 is a potent 4-oxoquinolizine antibiotic that selectively inhibits bacterial topoisomerase. It shows in vitro activity against both sensitive and resistant strains of B. pseudomallei, and it is also effective against other dangerous pathogens such as Burkholderia mallei, Bacillus anthracis, Yersinia pestis, and Francisella tularensis. In a murine model of melioidosis, oral administration of GC-072 demonstrated dose-dependent survival benefits, indicating its potential as a first-line oral treatment option for melioidosis.

NH-3 is a potent orally active thyroid hormone receptor (THR) antagonist which exhibits reversible behavior, demonstrated by an IC 50 of 55 nM. Derived from the selective thyromi-metic GC-1, NH-3 effectively inhibits the binding of thyroid hormones to their respective receptors, resulting in hindered cofactor recruitment.

(-)-Gallocatechin ((−)-GC) has free radical scavenging ability and moderate affinity to the human cannabinoid receptor.

Rucosopasem manganese (GC4711) is a potent and selective superoxide dismutase (SOD) mimetic that efficiently converts superoxide to hydrogen peroxide. Designed for research purposes, this compound shows promise in cancer-related studies.

Sobetirome (IACS-010759) is a selective agonist of thyroid hormone receptor β (TRβ) and binds selectively to TRβ-1 (EC50: 0.16 μM).

LM9 is a MyD88 inhibitor which prevents atherosclerosis by regulating inflammatory responses and oxidative stress in macrophages.

MX106 is a survivin inhibitor which induces degradation of XIAP and/or cIAP1, and suppresses genotoxic NF-kappaB activation.

Fresolimumab (GC1008) is a specific human anti-transforming growth factor β monoclonal antibody that binds to the active forms of human TGFβ1, TGFβ2, and TGFβ3 and can be used to study focal segmental glomerulosclerosis and cancer in adults.

Plecanatide acetate is an analogue of Uroguanylin. It is an orally active guanylate cyclase-C (GC-C) receptor agonist.

GC-IN-2 (Compound 25) is an effective and selective non-sugar-based glucocerebrosidase inhibitor with an IC50 value of 6.46 μM. It is utilized in research related to Gaucher's disease.

GC-78-HCl is an orally active, non-peptidic SARS-CoV-2 Mpro inhibitor with an enzyme IC50 of 0.19 μM. It exhibits strong anti-coronavirus activity and favorable pharmacokinetic properties.

GC7 Sulfate is an inhibitor of deoxyhypusine synthase (DHPS).

GC373, an effective inhibitor of the SARS-CoV-2 M pro, impedes virus replication, exhibiting an inhibition concentration (IC 50) of 0.4 μM. This compound is valuable for use in anti-COVID-19 research.

GC813 is a potent and permeable inhibitor of MERS coronavirus 3CL protease. GC813 is analogue of GC376.

Anti-GC1q R/C1QBP Antibody (60.11) is a mouse IgG1, κ chimeric antibody designed to target human GC1q R/C1QBP. The recommended isotype control for this antibody is Mouse IgG1 kappa, Isotype Control.

Neu5Gc(α2,6)N-Acetylgalactosamine is a type of biochemical reagent used in glycoscience research. Glycoscience studies the structure, synthesis, biology, and evolution of sugars. This field encompasses carbohydrate chemistry, the enzymatic formation and degradation of glycans, protein-glycan interactions, and the roles of glycans within biological systems. It is closely connected to fundamental research, biomedicine, and biotechnology.

C18:0 GM2(Neu5Gc) Ceramide (d18:1/18:0) is a type of sphingolipid.