p 4

EtDO-P4 is a nanomolar inhibitor of sphingolipid (GSL) synthesis, inhibiting EGFR-induced activation of the ERK pathway and various receptor tyrosine kinases (RTK). EtDO-P4 can be used to study a variety of tumor types, including Burkitt's lymphoma.

TAT-P4-(DATC5)2 TFA, a high-affinity peptide inhibitor targeting the PDZ domain of protein interacting with C kinase-1 (PICK1), exhibits a K i of 1.7 nM and demonstrates potential in mitigating addiction behaviors in rats [1].

TAT-P4-(DATC5)2 is a potent peptide inhibitor of the PDZ domain of protein interacting with C kinase-1 (PICK1), with a high affinity dissociation constant (K_i) of 1.7 nM. This compound has demonstrated the ability to mitigate addiction behaviors in rat models [1].

Pardaxin P 4 is an antimicrobial peptide found in the secretions of the Red Sea Moses sole (Red Sea Moses sole). It functions as a biolfilm perforating agent, interacting with phospholipid bilayers of varying compositions to induce cytotoxicity and pore formation. Pardaxin P 4 is used in the research of antimicrobial.

PI5P4Ks-IN-2 is an inhibitor of the phosphatidylinositol 5-phosphate 4-kinase PI5P4Kγ. Targeting the PI5P4K isoforms, PI5P4Ks-IN-2 inhibited PI5P4Kα, PI5P4Kβ, PI5P4Kγ, and PI5P4Kγ+, with IC50 values of <4.3, <4.6, 6.2, and 0.32, respectively.

D-myo-Inositol-1,2,4,5-tetraphosphate (DL-Ins-(1,2,4,5)P4) tetrasodium is the racemic regioisomer of inositol tetraphosphate (IP4s). It acts as an Ins(1,4,5)P3 receptor agonist with a Ki of 11 nM. Additionally, it can induce Ca2+ mobilization with an EC50 of 0.22 μM in CHO cells.

D-myo-Inositol-2,3,5,6-tetraphosphate (2,3,5,6-IP4) tetrasodium is an inositol phosphate utilized in the study of calcium channels.

Progesterone-3-biotinyl Photoaffinity Probe is a compound containing the active substance progesterone. It is utilized in studies related to sperm activation mechanisms.

D-myo-Inositol-1,4,5,6-tetraphosphate tetrasodium (Inositol 1,4,5,6-tetraphosphate tetrasodium) is one of the isomers of inositol oligophosphates. At concentrations of 8-10 μM, it almost completely inhibits calcium-activated chloride channels (chloride channels).

P4Q-391 is an inhibitor of the Plasmodium cytochrome bc1 complex (cytochrome bc1 complex) and exhibits antimalarial activity. It holds potential for use in parasitological research.

PI5P4Ks-IN-1 (compound 7) is an active compound that interacts with PI5P4Kγ[1].

PI5P4Kα-IN-1 (Compound 13) is a phosphatidylinositol 5-phosphate 4-kinase (PI5P4K) inhibitor with IC50 values of 2 μM for PI5P4Kα and 9.4 μM for PI5P4Kβ, potentially applicable in cancer, metabolic, and immunological disorder studies [1].

P4pal10, a PAR 4 antagonist, inhibits thrombin-mediated aggregation of mouse platelets in vivo and significantly diminishes Carrageenan-induced edema and granulocyte infiltration [1].

PI5P4K-β-IN-2 (compound d5) is a potent inhibitor of the PI5P4K-β enzyme with an IC50 value of 0.35 μM and exhibits antitumor activity.

PI5P4K-β-IN-1 (compound vs1) is a potent PI5P4K-β inhibitor with an IC50 of 0.80 μM [1].

PI5P4Ks-IN-3 (compound 30) is a covalent inhibitor of PI5P4K with inhibition constants (IC50s) of 1.34 μM for PI5P4Kα and 9.9 μM for PI5P4Kβ, but demonstrates weak cellular activity [1].

PI5P4Kγ-IN-1 (compound 2), a selective PI5P4Kγ inhibitor, facilitates mTORC1 signaling in MCF-7 breast cancer cells and aids in further characterization of PI5P4Kγ within these cells [1].

Ap4A (1, 10 µM; 24 h) induces apoptosis in HL60 cells.

Ap4A tetraammonium, a conserved second messenger across organisms from bacteria to humans, binds and activates the transcription of MITF downstream genes in conjunction with histidine triad nucleotide-binding protein 1 (HINT1). Additionally, Ap4A tetraammonium induces cell apoptosis (apoptosis).

D-myo-Inositol-1,4,5,6-tetraphosphate (D-Ins(1,4,5,6)P4) is an isomer of inositol polyphosphate. At concentrations of 8-10 μM, it almost entirely inhibits calcium-activated chloride channels.

P4pal10 TFA, the TFA salt form of P4pal10, serves as an antagonist of the protease-activated receptor 4 (PAR4). This compound inhibits platelet aggregation and thrombin generation induced by tissue factor (TF), exhibiting anticoagulant and antithrombotic activities. Additionally, P4pal10 TFA alleviates carrageenan-induced edema and neutrophil infiltration, and ameliorates damage in rat myocardial ischemia/reperfusion (I/R) models.

L2P4 is a peptide-based fluorescent probe targeting EBNA1 that inhibits the homodimerization of EBNA1 and selectively suppresses the growth of EBV+ tumors. Exhibiting cytotoxicity in EBV-positive C666-1 cells, L2P4 has an LC50 of 46.4 μM.

L2P4 TFA is a peptide-based fluorescent probe targeting EBNA1, capable of hindering the formation of EBNA1 homodimers and selectively suppressing the growth of EBV+ tumors. It demonstrates cytotoxicity in EBV-positive C666-1 cells, with an LC50 of 46.4 μM.

p38α inhibitor 4 is a selective MAPK p38α inhibitor, which is used to study diabetes, pain and chronic inflammation.