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DNA Gyrase/ribosomes-IN-1
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Catalog No. T217938 Copy Product Info
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DNA Gyrase/ribosomes-IN-1 is an inhibitor of bacterial ribosomes (ribosome) and DNA gyrase (DNA gyrase), with IC50 values of 1.11 μM and 3.31 μM, respectively. It also inhibits CYP3A4 with an IC50 of 18.5 μM and demonstrates stability in mouse plasma and liver microsomes. By interacting with ribosomal RNA and associated sites, DNA Gyrase/ribosomes-IN-1 can inhibit bacterial protein synthesis, and by interacting with the gyrase complex, it hinders bacterial DNA replication. It can restore activity against macrolide-resistant Gram-positive pathogens mediated by erm and enhances activity against Gram-negative bacteria such as Haemophilus influenzae (H. influenzae) and Moraxella catarrhalis (M. catarrhalis). DNA Gyrase/ribosomes-IN-1 is applicable for the study of community-acquired bacterial pneumonia.
DNA Gyrase/ribosomes-IN-1
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | Inquiry | Inquiry | |
| 50 mg | Inquiry | Inquiry | Inquiry |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Storage & Solubility Information
| Description | DNA Gyrase/ribosomes-IN-1 is an inhibitor of bacterial ribosomes (ribosome) and DNA gyrase (DNA gyrase), with IC50 values of 1.11 μM and 3.31 μM, respectively. It also inhibits CYP3A4 with an IC50 of 18.5 μM and demonstrates stability in mouse plasma and liver microsomes. By interacting with ribosomal RNA and associated sites, DNA Gyrase/ribosomes-IN-1 can inhibit bacterial protein synthesis, and by interacting with the gyrase complex, it hinders bacterial DNA replication. It can restore activity against macrolide-resistant Gram-positive pathogens mediated by erm and enhances activity against Gram-negative bacteria such as Haemophilus influenzae (H. influenzae) and Moraxella catarrhalis (M. catarrhalis). DNA Gyrase/ribosomes-IN-1 is applicable for the study of community-acquired bacterial pneumonia. |
| Targets & IC50 | CYP3A4:18.5 μM |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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