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HE4-1 leech peptide

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Catalog No. TP4325 Copy Product Info
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HE4-1 leech peptide is a p38 MAPK inhibitor with additional c-Jun N-terminal kinase (JNK) inhibitory properties. It can suppress macrophage migration without significantly affecting the phagocytic ability, lysozyme activity, or expression levels of various inflammatory factors in macrophages. HE4-1 leech peptide is applicable for atherosclerosis research.

HE4-1 leech peptide

Cas No. 2531396-44-6
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For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction

Bioactivity
Description
HE4-1 leech peptide is a p38 MAPK inhibitor with additional c-Jun N-terminal kinase (JNK) inhibitory properties. It can suppress macrophage migration without significantly affecting the phagocytic ability, lysozyme activity, or expression levels of various inflammatory factors in macrophages. HE4-1 leech peptide is applicable for atherosclerosis research.
In vitro
HE4-1 leech peptide (200-800 μg/mL; following 2 hours of LPS pretreatment, applied for 24 hours) inhibits LPS-induced migration of RAW264.7 macrophages via the p38 MAPK and JNK signaling pathways, while also downregulating the transcription of MEKK4 and ASK2. At concentrations up to 800 μg/mL, HE4-1 leech peptide does not significantly affect the phagocytic capacity, lysozyme activity, or the secretion of IL-1β, IL-6, or IL-12 in RAW264.7 macrophages, but it enhances TNF-α secretion at 400 μg/mL and 800 μg/mL.
Chemical Properties
Molecular Weight1429.49
FormulaC59H96N16O25
Cas No.2531396-44-6
SmilesC([C@@H](NC(CNC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@@H](NC([C@H](CCC(O)=O)N)=O)C)=O)=O)CO)=O)C)=O)CCCCN)=O)CCC(O)=O)=O)CC(C)C)=O)CCC(O)=O)=O)=O)CC(O)=O)(=O)N1[C@H](C(N[C@H](C(N[C@H](C(NCC(O)=O)=O)C)=O)[C@@H](C)C)=O)CCC1
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 µL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
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2 Enter the in vivo formulation:
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Related Tags: HE4-1 leech peptide in vitro | HE4-1 leech peptide formula | HE4-1 leech peptide molecular weight
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