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WGYRGFYC
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Catalog No. TP4322 Copy Product Info
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WGYRGFYC (WC8) is a peptide that selectively targets HER2 by mimicking the antigen-binding site of trastuzumab to bind specifically to HER2. Its DOTA precursor exhibits a dissociation constant (KD) of 61.20 nM for HER2. WGYRGFYC enables specific and highly sensitive detection of HER2 expression in HER2-positive breast cancer cells and tumor tissues, monitoring dynamic downregulation of HER2 expression. The compound rapidly distributes to target tissues and is efficiently cleared from non-target tissues through the kidneys, offering an optimal tumor-to-background ratio for imaging. It is a component of the PET radiotracer Ga-DOTA-WC8 and shows no significant cytotoxicity in breast cancer cells, making it suitable for non-invasive imaging diagnosis and treatment evaluation of HER2-positive breast cancer [1].
WGYRGFYC
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | Inquiry | Inquiry | |
| 50 mg | Inquiry | Inquiry | Inquiry |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Storage & Solubility Information
| Description | WGYRGFYC (WC8) is a peptide that selectively targets HER2 by mimicking the antigen-binding site of trastuzumab to bind specifically to HER2. Its DOTA precursor exhibits a dissociation constant (KD) of 61.20 nM for HER2. WGYRGFYC enables specific and highly sensitive detection of HER2 expression in HER2-positive breast cancer cells and tumor tissues, monitoring dynamic downregulation of HER2 expression. The compound rapidly distributes to target tissues and is efficiently cleared from non-target tissues through the kidneys, offering an optimal tumor-to-background ratio for imaging. It is a component of the PET radiotracer Ga-DOTA-WC8 and shows no significant cytotoxicity in breast cancer cells, making it suitable for non-invasive imaging diagnosis and treatment evaluation of HER2-positive breast cancer [1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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