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Catestatin (rat) (Synonyms: Rat chromogranin A367–387)
Catalog No. TP4032 Copy Product Info
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Catestatin (rat) (Rat chromogranin A367–387) is a potent, reversible, non-competitive, and non-cooperative nicotinic acetylcholine receptor (nAChR) antagonist derived from chromogranin A (A367-387). It inhibits norepinephrine release in rat PC12 pheochromocytoma cells (IC50= 1.2 μM) and blocks norepinephrine release desensitization (IC50= 0.62 μM). Catestatin (rat) exerts anti-adrenergic effects via the endothelial PI3K-AKT-eNOS pathway in rat papillary muscle and isolated cardiomyocytes. In ischemia/reperfusion myocardial cells, it maintains mitochondrial membrane potential and increases phosphorylation of AKT at S473, GSK3β at S9, PLB at T17, and eNOS at S1179. Additionally, Catestatin (rat) reverses 22Na+ uptake desensitization. This compound is useful for studying the regulation of nicotinic cholinergic receptors and catecholamine release control mechanisms.
Catestatin (rat)
Copy Product Info🥰Excellent
Catalog No. TP4032
Synonyms Rat chromogranin A367–387
Catestatin (rat) (Rat chromogranin A367–387) is a potent, reversible, non-competitive, and non-cooperative nicotinic acetylcholine receptor (nAChR) antagonist derived from chromogranin A (A367-387). It inhibits norepinephrine release in rat PC12 pheochromocytoma cells (IC50= 1.2 μM) and blocks norepinephrine release desensitization (IC50= 0.62 μM). Catestatin (rat) exerts anti-adrenergic effects via the endothelial PI3K-AKT-eNOS pathway in rat papillary muscle and isolated cardiomyocytes. In ischemia/reperfusion myocardial cells, it maintains mitochondrial membrane potential and increases phosphorylation of AKT at S473, GSK3β at S9, PLB at T17, and eNOS at S1179. Additionally, Catestatin (rat) reverses 22Na+ uptake desensitization. This compound is useful for studying the regulation of nicotinic cholinergic receptors and catecholamine release control mechanisms.
Catestatin
(rat)
(rat)
| Pack Size | Price | USA Stock | Global Stock | Quantity |
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| 10 mg | Inquiry | Inquiry | Inquiry | |
| 50 mg | Inquiry | Inquiry | Inquiry |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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| Description | Catestatin (rat) (Rat chromogranin A367–387) is a potent, reversible, non-competitive, and non-cooperative nicotinic acetylcholine receptor (nAChR) antagonist derived from chromogranin A (A367-387). It inhibits norepinephrine release in rat PC12 pheochromocytoma cells (IC50= 1.2 μM) and blocks norepinephrine release desensitization (IC50= 0.62 μM). Catestatin (rat) exerts anti-adrenergic effects via the endothelial PI3K-AKT-eNOS pathway in rat papillary muscle and isolated cardiomyocytes. In ischemia/reperfusion myocardial cells, it maintains mitochondrial membrane potential and increases phosphorylation of AKT at S473, GSK3β at S9, PLB at T17, and eNOS at S1179. Additionally, Catestatin (rat) reverses 22Na+ uptake desensitization. This compound is useful for studying the regulation of nicotinic cholinergic receptors and catecholamine release control mechanisms. |
| In vivo | When Catestatin (rat) (50 nL, 1 mM dissolved in PBS) is injected into the RVLM of normotensive rats with vagal nerve ablation, it results in sympathetic activation. |
| Synonyms | Rat chromogranin A367–387 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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