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DOTA-C1-FAP-2286

Name: DOTA-C1-FAP-2286
Brand: TargetMol
SKU: TP4319
Rating: 4.5 (1 reviews)

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DOTA-C1-FAP-2286 is a cysteine-modified radioligand that targets fibroblast activation protein (FAP). It binds competitively to FAP with an IC50 of 127.64 nM. This compound targets and accumulates in FAP-expressing cells and exhibits rapid renal clearance. DOTA-C1-FAP-2286 can be utilized as a PET/CT tracer in cancer research.

DOTA-C1-FAP-2286

Cas No. 3107530-08-2

Pack Size	Price	USA Stock	Global Stock	Quantity
10 mg	Inquiry	Inquiry	Inquiry
50 mg	Inquiry	Inquiry	Inquiry

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Product Introduction

Bioactivity

Description	DOTA-C1-FAP-2286 is a cysteine-modified radioligand that targets fibroblast activation protein (FAP). It binds competitively to FAP with an IC50 of 127.64 nM. This compound targets and accumulates in FAP-expressing cells and exhibits rapid renal clearance. DOTA-C1-FAP-2286 can be utilized as a PET/CT tracer in cancer research.
In vitro	DOTA-C1-FAP-2286 competitively binds to [177 Lu]Lu-FAP-2286 in A549-FAP cells, with an IC50 of 127.64 ± 23.40 nM, within a concentration range of 10^−11 to 10^−5 M over 60 minutes.
In vivo	DOTA-C1-FAP-2286 ([68 Ga]Ga-FAP-C1−2286) (intravenous injection; single dose) shows significant accumulation in tumors of 549-FAP tumor-bearing mice and demonstrates superior renal clearance.

Chemical Properties

Molecular Weight	1773.06
Formula	C₇₃H₁₀₉N₁₅O₂₆S₅
Cas No.	3107530-08-2
Smiles	O=C1[C@]2(N(C(=O)[C@@H](NC(CCCCC)=O)CSCC=3C=C(C=C(CSCCNC([C@@H](NC([C@@H](NC(CN4CCN(CC(O)=O)CCN(CC(O)=O)CCN(CC(O)=O)CC4)=O)CS(=O)(=O)O)=O)CS(=O)(=O)O)=O)C3)CSC[C@@H](C(O)=O)NC(=O)[C@H](CC5=CC=CC=C5)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@]([C@@H](C)O)(NC(=O)[C@]6(N1CCC6)[H])[H])CCC2)[H]

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Related Tags: DOTA-C1-FAP-2286 in vivo | DOTA-C1-FAP-2286 in vitro | DOTA-C1-FAP-2286 formula | DOTA-C1-FAP-2286 molecular weight