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mcIRBP-9
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Catalog No. TP4444 Copy Product Info
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mcIRBP-9 is an NF-κB inhibitor with oral bioavailability. It reduces levels of TNF-α, IL-1β, and TGF-β1 in renal tissue, while also decreasing LPS-induced IL-1β production. mcIRBP-9 is suitable for research associated with diabetic nephropathy and type 2 diabetes.
mcIRBP-9
Cas No. 1489241-80-6
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | Inquiry | Inquiry | |
| 50 mg | Inquiry | Inquiry | Inquiry |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | mcIRBP-9 is an NF-κB inhibitor with oral bioavailability. It reduces levels of TNF-α, IL-1β, and TGF-β1 in renal tissue, while also decreasing LPS-induced IL-1β production. mcIRBP-9 is suitable for research associated with diabetic nephropathy and type 2 diabetes. |
| In vivo | Administered orally either once daily or as a single dose over 12 weeks or short-term, mcIRBP-9 (1-10 μmol kg−1) enhances glucose clearance in a dose-dependent manner, reduces long-term blood glucose and HbA1c levels, elevates survival rates to 100%, and ameliorates diabetic nephropathy in db/db mice through anti-inflammatory and renal protective effects. Additionally, a single oral dose of mcIRBP-9 (1 μmol kg−1) post-LPS stimulation inhibits LPS-induced renal NF-κB activity and systemic IL-1β production in NF-κB transgenic mice, demonstrating anti-inflammatory activity related to kidney disease. |
| Molecular Weight | 923.11 |
| Formula | C42H74N12O11 |
| Cas No. | 1489241-80-6 |
| Smiles | C(=O)([C@H]1N(C([C@@H](NC([C@@H](NC([C@@H](NC([C@H]([C@H](CC)C)N)=O)C(C)C)=O)C)=O)CCCNC(=N)N)=O)CCC1)N2[C@H](C(N[C@H](C(N[C@H](C(NCC(O)=O)=O)[C@H](CC)C)=O)[C@@H](C)O)=O)CCC2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: mcIRBP-9 in vivo | mcIRBP-9 formula | mcIRBP-9 molecular weight
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