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CYP51-IN-32
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Catalog No. T217899 Copy Product Info
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CYP51-IN-32 is an antifungal agent with an IC50 of 0.331 μM against Candida albicans CYP51. It releases hydrogen sulfide (H2S) and inhibits hyphal formation and biofilm development in Candida albicans. CYP51-IN-32 can be prepared as PEG-based nanovesicles and is useful for research on Candida albicans infections.
CYP51-IN-32
Cas No. 205251-67-8
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks | 10-14 weeks |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | CYP51-IN-32 is an antifungal agent with an IC50 of 0.331 μM against Candida albicans CYP51. It releases hydrogen sulfide (H2S) and inhibits hyphal formation and biofilm development in Candida albicans. CYP51-IN-32 can be prepared as PEG-based nanovesicles and is useful for research on Candida albicans infections. |
| Targets & IC50 | CYP51:0.331 μM |
| In vitro | CYP51-IN-32 (Compound 3j) effectively inhibits the growth of Candida albicans with a MIC of 4.68 μg/mL. The antifungal activity against Candida albicans decreases when H2S is eradicated by 1.5 mg/mL MgO, resulting in a raised MIC of 32 μg/mL. This compound significantly hampers the hyphal formation of Candida albicans, maintaining it in a unicellular yeast form. At a concentration of 0.0005 mg/mL, CYP51-IN-32 reduces Candida albicans biofilm formation by 60%. Additionally, the IC50 for CYP51-IN-32 against WS-1 human skin fibroblasts is 65.73 μg/mL, giving a selectivity index of approximately 14.0 relative to its antifungal MIC against Candida albicans. |
| Molecular Weight | 390.95 |
| Formula | C19H19ClN2OS2 |
| Cas No. | 205251-67-8 |
| Smiles | O=C(C1=CC=C(Cl)C=C1)CSC(=S)N2CCN(C=3C=CC=CC3)CC2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: CYP51-IN-32 in vitro | CYP51-IN-32 formula | CYP51-IN-32 molecular weight
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