6 chloro 1 tetralone

6-Chloro-1-tetralone (6-chloro-3;5-Chloro-1-Indomone) is an important intermediate for the synthesis of pharmaceutical compounds.

1-(6-Methoxy-2-naphthyl)ethanol is used as pharmaceutical intermediates.

Boscalid is a broad-spectrum carboxamide fungicide that inhibits fungal respiration by binding to the ubiquinone site of mitochondrial complex II succinate dehydrogenase.1It suppresses mycelial growth ofS. minorby 87 to 100% and ofS. sclerotiorumby 77 to 100% when used at a concentration of 1 μg ml.2In field studies, boscalid applied at 5.6 μg cm2provides 55.5 and 30.4% disease control for lettuce drop caused byS. minorandS. sclerotiorum, respectively. It decreases cell viability of mouse primary cortical neurons following long-term exposure but is not cytotoxic (LC50= >100 μM for acute and continuous exposure). Formulations containing boscalid have been used in agriculture to prevent fungal growth on crops. 1.Wang, Y., Duan, Y., Wang, J., et al.A new point mutation in the iron-sulfur subunit of succinate dehydrogenase confers resistance to boscalid in Sclerotinia sclerotiorumMol. Plant Pathol.16(7)653-661(2015) 2.Matheron, M.E., and Porchas, M.Activity of boscalid, fenhexamid, fluazinam, fludioxonil, and vinclozolin on growth of Sclerotinia minor and S. sclerotiorum and development of lettuce dropPlant Dis.88(6)665-668(2004)

Butyl cinnamate is an agent of mosquito repellent.

Lysophosphatidylcholines (Lyso-Lecithins (egg)) are orally active lipids that induce cell damage and apoptosis, and induce demyelination. Lysophosphatidylcholines play a role in mediating inflammation, fibrosis, and cancer, and can be used to study atherosclerosis.

Nocardamine is a ferrioxamine siderophore that has been found inStreptomycesand has diverse biological activities.1,2,3,4It chelates iron in a chrome azurol S assay (IC50= 9.9 μM).1Nocardamine inhibitsM. smegmatisandM. bovisbiofilm formation (MIC = 10 μM for both), an effect that can be reversed by iron.2It is cytotoxic to T47D, SK-MEL-5, SK-MEL-28, and RPMI-7951 cancer cells (IC50s = 6, 18, 12, and 14 μM, respectively).3Nocardamine also induces morphological changes in BM-N4 insect cells.4 1.Lopez, J.A.V., Nogawa, T., Futamura, Y., et al.Nocardamin glucuronide, a new member of the ferrioxamine siderophores isolated from the ascamycin-producing strain Streptomyces sp. 80H647J. Antibiot. (Tokyo)72(12)991-995(2019) 2.Ishida, S., Arai, M., Niikawa, H., et al.Inhibitory effect of cyclic trihydroxamate siderophore, desferrioxamine E, on the biofilm formation of Mycobacterium speciesBiol. Pharm. Bull.34(6)917-920(2011) 3.Kalinovskaya, N.I., Romaneko, L.A., Irisawa, T., et al.Marine isolate Citricoccus sp. KMM 3890 as a source of a cyclic siderophore nocardamine with antitumor activityMicrobiol. Res.166(8)654-661(2011) 4.Matsubara, K., Sakuda, S., Tanaka, M., et al.Morphological changes in insect BM-N4 cells induced by nocardamineBiosci. Biotechnol. Biochem.62(10)2049-2051(1998)

2-Amino-6-chloropurine is a precursor in the synthesis of nucleoside analogs with antiviral activity against Epstein-Barr virus (EBV) and human herpes virus 6 (HHV-6).1 1.Qiu, Y.-L., Ksebati, M.B., Ptak, R.G., et al.(Z)- and (E)-2-((hydroxymethyl)cyclopropylidene)methyladenine and -guanine. New nucleoside analogues with a broad-spectrum antiviral activityJ. Med. Chem.41(1)10-23(1998)

Gadoleic acid is a monounsaturated fatty acid.1,2It inhibits the dsDNA binding activity of p53 when used at a concentration of 1.2 nM.1Hepatic levels of gadoleic acid are reduced in rats fed a high-fat or a high-fat high-cholesterol diet and increased in rats fed a high-cholesterol diet.2 1.Iijima, H., Kasai, N., Chiku, H., et al.The inhibitory action of long-chain fatty acids on the DNA binding activity of p53Lipids41(6)521-527(2006) 2.Serviddio, G., Bellanti, F., Villani, R., et al.Effects of dietary fatty acids and cholesterol excess on liver injury: A lipidomic approachRedox Biol.9296-305(2016)

Sphingosine-1-phosphate (S1P) is a bioactive lipid that exhibits a broad spectrum of biological activities including cell proliferation, survival, migration, cytoskeletal organization, and morphogenesis. It exerts its activity by binding to five distinct G protein-coupled receptors, S1P1 EDG-1, S1P2 EDG-5, S1P3 EDG-3, S1P4 EDG-6, and S1P5 EDG-8. W140 is an inactive enantiomer of W146, a selective S1P1 antagonist (Ki = 77 nM), that binds to the S1P1 receptor with a Ki of 4.6 μM (2a = W146; 2b = W140 in supplemental material). It exhibits no biological activity in vivo and can therefore serve as an effective control compound for experiments involving W146.

Sodium heptane-1-sulfonate is a useful organic compound for research related to life sciences. The catalog number is T67130 and the CAS number is 22767-50-6.

1-Stearoyl-2-docosahexaenoyl-sn-glycerol (18:0-22:6 DG) is a diacylglycerol capable of binding to RasGRP and modulating the activation of MAP kinases.

6-Me-ATP (N6-Methyl-ATP) trisodium, an N6-modified ATP derivative, exhibits high binding affinity for GSK3 and effectively serves as the phosphate group donor in GSK3β-catalyzed phosphorylation of its substrate peptide [1].

6-Oxohexyl 2-hexyldecanoate is a lipid product utilized for drug delivery [1].

Decanoic acid, 2-hexyl-, 6-oxohexyl ester-1, is a lipid compound utilized in drug delivery systems [1].

Heptadecan-9-yl 8-((6-(decyloxy)-6-oxohexyl)(2-hydroxyethyl)amino)octanoate is employed in lipid nanoparticle (LNP) delivery systems for mRNA vaccine delivery [1].

6-Bromohexyl 2-hexyldecanoate, a lipid, serves as a precursor in the synthesis of lipid nanoparticles and nanomaterials [1].

(Z)-non-6-en-1-ol (cis-6-Nonen-1-ol) is a volatile substance contained in melons and can be used to detect the freshness of melons and fruits.

LNP Lipid-7 (Compound 7013) is a lipid utilized in the formulation of lipid nanoparticles (LNP) for efficient drug delivery [1].

CL4F8-6, an ionizable cationic lipid with a pKa of 6.14, is utilized in lipid nanoparticles (LNPs) for mRNA therapeutics. When incorporated into LNPs delivering Cas9 mRNA and sgRNA, CL4F8-6 facilitates CRISPR-mediated gene knockdown in mice [1].

Docosapentaenoic acid (DPA), a 22-carbon fatty acid primarily found in fish oil, constitutes a minor fraction of the total unsaturated fatty acids in human serum, with concentrations ranging from 0.1% to 1%, which can increase through dietary supplementation. The all-cis-4,7,10,13,16-DPA variant, also known as Austrian acid, represents a specific isomer of DPA and falls into the omega-6 category, synthesized through the elongation and desaturation of arachidonic acid. In conditions such as fatty acid desaturase syndrome, its levels may decrease, potentially influencing development. Furthermore, conditions like nonalcoholic steatohepatitis, a precursor to hepatocellular carcinoma, are marked by enhanced expression of the hepatic elongase very long fatty acid protein 6 and increased concentrations of very long-chain fatty acids, including all-cis-4,7,10,13,16-DPA.

CS-0047390, also known as tert-Butyl-DCL, PSMA inhibitor, is a radiopaque peptide reagent.

Ethyl 6-deoxy-2,3,4-tris-O-(phenylmethyl)-1-thio-L-galactopyranoside is a biochemical reagent utilized in glycobiology research. Glycobiology investigates the structure, synthesis, biology, and evolution of sugars, encompassing carbohydrate chemistry, glycan biosynthesis and degradation enzymology, protein-glycan interactions, and the role of glycans in biological systems. This field is closely related to fundamental research, biomedicine, and biotechnology.

6-Azido-6-deoxy-2,3-O-(1-methylethylidene)-α-L-sorbofuranose is a reagent used in biochemical reactions.

Phenyl 6-deoxy-2-O-(phenylmethyl)-1-thio-α-L-mannopyranoside is a reagent used in biochemical reactions.