2-chloro-5-thiophenecarboxaldehyde

2-Chloro-5-thiophenecarboxaldehyde is a biochemical reagent that can be used as a biomaterial for life science related research and as a sulfonylation reagent for organic synthesis and drug discovery.

p-Menthane-3,8-diol (2-(2-hydroxypropan-2-yl)-5-methylcyclohexan-1-ol) is a cyclohexanol that is used in organic synthesis and biochemical experiments.

2-(4-methyl-1,3-thiazol-5-yl)ethyl decanoate is a long-chain fatty acid ester containing thiazole that is used in organic synthesis and biochemical experiments.

Dmt-2'fluoro-da(bz) amidite is a 2'-deoxy-2'-fluoro-phosphorothioate oligonucleotide with high affinity and specificity for RNA targets and serves as an intermediate in the synthesis of 5'-DMT-3'-phosphoramidite, an antisense compound resistant to nuclease.

5'-O-Tritylthymidine is a blocker of the formation of the FAK Mdm-2 complex. 5'-O-Tritylthymidine activates p53 and caspase-8. It also leads to increase detachment and apoptosis in breast and colon cancers.

5-Carboxy-2-thiouracil is a compound with antitumor activity that forms complexes with metal ions, exhibiting significant biological effects.

2-Deoxy-D-ribonic-1,4-lactone ((4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-one) is an oxolane-containing compound used in organic synthesis and biochemical experiments.

Methyl 8-(3-octyloxiran-2-yl)octanoate (Methyl 9,10-epoxystearat) is an organic compound containing an epoxy group and an ester group for use in organic synthesis and biochemical experiments.

Acetylcholine perchlorate is the perchlorate salt of acetylcholine. Acetylcholine, an endogenous neurotransmitter at cholinergic synapses, could amplify the action potential of the sarcolemma following by inducing muscle contractions.

Guanylyl Imidodiphosphate trisodium (Guanosine 5'-[β,γ-imido]triphosphate), a non-hydrolysable GTP analogue, activates ADP-ribosylation factor (ARF) and strongly stimulates adenylate cyclase. It is utilized in protein synthesis studies [1] [2] [3].

Nocardamine is a ferrioxamine siderophore that has been found inStreptomycesand has diverse biological activities.1,2,3,4It chelates iron in a chrome azurol S assay (IC50= 9.9 μM).1Nocardamine inhibitsM. smegmatisandM. bovisbiofilm formation (MIC = 10 μM for both), an effect that can be reversed by iron.2It is cytotoxic to T47D, SK-MEL-5, SK-MEL-28, and RPMI-7951 cancer cells (IC50s = 6, 18, 12, and 14 μM, respectively).3Nocardamine also induces morphological changes in BM-N4 insect cells.4 1.Lopez, J.A.V., Nogawa, T., Futamura, Y., et al.Nocardamin glucuronide, a new member of the ferrioxamine siderophores isolated from the ascamycin-producing strain Streptomyces sp. 80H647J. Antibiot. (Tokyo)72(12)991-995(2019) 2.Ishida, S., Arai, M., Niikawa, H., et al.Inhibitory effect of cyclic trihydroxamate siderophore, desferrioxamine E, on the biofilm formation of Mycobacterium speciesBiol. Pharm. Bull.34(6)917-920(2011) 3.Kalinovskaya, N.I., Romaneko, L.A., Irisawa, T., et al.Marine isolate Citricoccus sp. KMM 3890 as a source of a cyclic siderophore nocardamine with antitumor activityMicrobiol. Res.166(8)654-661(2011) 4.Matsubara, K., Sakuda, S., Tanaka, M., et al.Morphological changes in insect BM-N4 cells induced by nocardamineBiosci. Biotechnol. Biochem.62(10)2049-2051(1998)

Deoxyguanosine triphosphate trisodium salt (2'-Deoxyguanosine-5'-triphosphate trisodium salt) is a nucleotide precursor for DNA synthesis in cells and can be used in the reverse transcription-polymerase chain reaction (RT-PCR) for DNA amplification.

Methyl alpha-eleostearate (α-ESA) is a conjugated polyunsaturated fatty acid commonly found in plant seed oil. This fatty acid accounts for about 60% of the total fatty acid composition of bitter gourd seed oil and about 70% in tung oil. α-ESA is metabolized and converted to conjugated linoleic acid (9Z,11E-CLA) in rats. It has shown potential as a tumor growth suppressor. In colon cancer Caco-2 cells, α-ESA induced apoptosis through up-regulation of GADD45, p53, and PPARγ. In DLD-1 cells supplemented with α-ESA, apoptosis was induced via lipid peroxidation with an EC50 of 20 μM. It also inhibits DNA polymerases and topoisomerases with IC50s ranging from ~5-20 μM for different isoforms of the enzymes. α-ESA methyl ester is a neutral, more lipid soluble form of the free acid.

5'-O-DMT-N4-Ac-dC (N4-Acetyl-2'-deoxy-5'-O-DMT-cytidine, compound 7) is a deoxynucleoside used in synthesizing dodecyl phosphoramidite, a crucial precursor for dod-DNA production. Dod-DNA is amphiphilic DNA with dodecyl phosphotriester linkages, featuring an internal hydrophobic region[1][2].

2'-Deoxyadenosine-5'-triphosphate trisodium (dATP trisodium) is a nucleotide substrate for DNA polymerase, essential for DNA synthesis and replication in cells.

Capsaicin, the chemical that imparts the spicy-hot quality of chili peppers, is produced by the fruits of plants belonging to the Capsicum family. 8-methyl Nonanoic acid is an immediate precursor of capsaicin as well as a by-product of capsaicin degradation.[1] Addition of 5 mM of 8-methyl nonanoic acid significantly increases the yield of capsaicin in both immobilized and freely suspended cells of C. frutescens. [2] Capsaicin has reported antimicrobial properties, however isocapric acid can act as a growth substrate in certain bacterial strains.[3]

2',3'-Dideoxy-5-iodocytidine, a chemical compound, is employed in gene sequencing and functions as an antibiotic. It exhibits significant efficacy specifically against Mycobacterium.

5'-O-(4,4'-Dimethoxytrityl)-2'-deoxyuridine (5'-O-DMT-dU) is a competitive inhibitor of dUTP nucleotidohydrolase (dUTPase) in E. coli with a Ki greater than 1 mM. 5'-O-(4,4'-Dimethoxytrityl)-2'-deoxyuridine can be used in machine-assisted DNA synthesis.

ddCTP, one of the 2',3'-dideoxyribonucleoside 5'-triphosphates (ddNTPs), functions as a chain-elongating inhibitor of DNA polymerase for DNA sequencing.

2-Hydroxy-5-nitrobenzoic acid is a useful organic compound for research related to life sciences. The catalog number is T64902 and the CAS number is 96-97-9.

Deoxycytidine triphosphate trisodium salt (2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE TRISODI) contributes to antibiotic lethality in stationary-phase mycobacteria.

Dideoxythymidine triphosphate trisodium (ddTTP), a 2',3'-dideoxyribonucleoside 5'-triphosphate (ddNTP), functions as a chain-elongation inhibitor of DNA polymerase in DNA sequencing applications [1].

ddUTP (lithium), at a concentration of 100mM in H20, serves as a nucleotide analog capable of being integrated into DNA, RNA, or other nucleic acids. It is applicable in DNA RNA hybridization experiments including Southern and Northern blots.