d3

5,6-trans-Vitamin D3(5,6-trans-Cholecalciferol) is an isoform of Vitamin D3, which is converted from Vitamin D3 on the skin surface after light exposure.

Vitamin D3 (Cholecalciferol) is a naturally occurring form of vitamin D that, after metabolic activation, can induce cell differentiation and cancer cell proliferation. It can also be used to establish kidney stone models.

Slingshot inhibitor D3 (JHN76359) is a potent inhibitor of the Protein Phosphatase Slingshot.

3-Hydroxy agomelatine-D3 is a deuterium labeled 3-Hydroxy agomelatine. 3-Hydroxy agomelatine (T10114) is an Agomelatine metabolite and a 5-HT2C receptor antagonist (IC50: 3.2 μM; Ki: 1.8 μM).

4-Hydroxyatomoxetine-D3 is a deuterium labeled 4-Hydroxyatomoxetine. 4-Hydroxyatomoxetine (T10145) is an active metabolite of Atomoxetine. 4-Hydroxyatomoxetine (T10145) is metabolized by CYP2D6. Atomoxetine is a noradrenaline reuptake inhibitor.

Acetazolamide-D3 is a deuterium-labeled Acetazolamide. Acetazolamide (T0813) is a potent carbonic anhydrase inhibitor.

Apixaban 13C,D3 is a deuterium labeling of Apixaban (T1736) for isotopic tracing. Apixaban 13C,D3 is a selective inhibitor of coagulation factor Xa and is used in thromboembolism studies

Clomipramine-D3 is the deuterium-labeled Clomipramine. Clomipramine (T21013) is a serotonin transporter, norepinephrine transporter dopamine transporter blocker (Ki: 0.14, 54 and 3 nM).

Clomipramine-D3 hydrochloride is the deuterium-labeled Clomipramine hydrochloride (TMSM-0794). Clomipramine is a serotonin transporter, norepinephrine transporter dopamine transporter blocker (Ki: 0.14, 54 and 3 nM).

Doxepin-D3 hydrochloride is a deuterium-labeled Doxepin Hydrochloride (TMSM-1071). Doxepin hydrochloride is an oral active tricyclic antidepressant used as a sedative. Doxepin hydrochloride is also an effective CYP450 inhibitor, significantly inhibiting CYP450 2C19 and 1A2. Doxepin hydrochloride is an effective selective histamine receptor H1 antagonist.

Duloxetine-D3 hydrochloride is a serotonin-norepinephrine reuptake inhibitor (SNRI) with a Ki of 4.6 nM, used for the treatment of major depressive disorder and generalized anxiety disorder (GAD). Duloxetine D3 hydrochloride ( (S)-Duloxetine D3 hydrochloride) is a deuterium-labeled Duloxetine hydrochloride (TMSM-3429).

Enzalutamide-D3 is a deuterium-labeled form of the androgen receptor antagonist Enzalutamide (T6002), retaining potent anti-androgen and antineoplastic activity with an IC50 of 36 nM in LNCaP prostate cancer cells, and is primarily used in pharmacokinetic, metabolic tracing, and drug interaction studies.

Fenpiverinium-D3 bromide is a deuterium labeled Fenpiverinium bromide.

Ivabradine-D3 hydrochloride is a new If inhibitor with IC50 of 2.9 μM, and used as a pure heart rate lowering agent. Ivabradine hydrochloride (TMSM-3413) is the deuterium labeled Ivabradine hydrochloride.

Methimazole-D3, a deuterium-labeled version of Methimazole, serves as an antithyroid medication for treating hyperthyroidism in both humans and animals.

Methylnaltrexone-D3 bromide is the deuterium-labeled Methylnaltrexone bromide (T21422).

Mirtazapine-D3 is a deuterium labeled Mirtazapine. Mirtazapine is an inhibitor of 5-HT receptor .

Mycophenolic acid-D3 is a derivative of Mycophenolic acid. Mycophenolic acid (T1335) is a compound that reduces GTP level and impacts transcription elongation of RNA polymerase II (RNAP II), promotes proximal site use and reverses the effect of cordyceps on selective polyadenylation.

Naratriptan-D3 hydrochloride, the deuterium-labeled form of Naratriptan Hydrochloride (T6602), is a selective agonist of the 5-HT1 receptor subtype.

Nicardipine-D3 hydrochloride is the deuterium labeled Nicardipine hydrochloride (T1215).

Olanzapine-D3 is the deuterium labeled Olanzapine (TMSM-3369).

Omeprazole-d3 is a stable deuterated derivative of omeprazole. Omeprazole is a selective proton pump inhibitor (PPI) used in research related to gastrointestinal diseases. Omeprazole inhibits the proliferation and adhesion of Helicobacter pylori and disrupts the stability of the bacterial cell membrane. Omeprazole inhibits the growth of both Gram-positive and Gram-negative bacteria.

Piroxicam-D3 is deuterium labeled Piroxicam. Piroxicam (T0758) is a COX inhibitor (human monocyte COX-1 and COX-2 with IC50s of 47, 25 μM , respectively) .

PSI-6206 13C,D3 is the deuterium labeled PSI-6206. PSI-6206 (T2117) is a potent and selective HCV NS5B polymerase inhibitor.