Bisdemethoxycurcumin (Standard) is the standard substance of Bisdemethoxycurcumin, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Bisdemethoxycurcumin (Curcumin III) is a natural demethoxy derivative of curcumin. It is a potent activator of macrophage phagocytosis, interacting with 1α, 25-dihydroxy vitamin D3 to stimulate amyloid-β clearance by macrophages (optimal stimulation at 100 nM BDMC) . More stable than curcumin in physiological media, BDMC suppresses proliferation of cancer cells . It down-regulates the transcriptional coactivator p300, suppressing the Wnt/β-catenin pathway, and inhibits LPS induction of iNOS expression .